“…The scope of these reactions is mostly limited to unsubstituted 2,2,2-trifluoroethylamines (R 1 =H), however, and reported reactions with 1-substituted-2,2,2-trifluoroethylamines mostly have an electron-withdrawing group as the substituent. [13][14][15] In addition, most of the reported reactions are limited to 1,3-dipolar cycloaddition with electron-deficient olefins, [6][7][8]10,11) and these cyclized products are not readily transformed into N-unprotected 2,2,2-trifluoroethylamines. 16) To overcome these limitations, herein we report our preliminary studies on Pd-catalyzed allylation of sp 3 C-H bonds of 1-mono-substituted 2,2,2-trifluoroethylamines, providing a variety of 1-allylated 2,2,2-trifluoroethylamines with tetrasubstituted carbon stereocenters.…”