The Stability Maintenance of Protein Drugs in Organic Coatings Based on Nanogels

Qi, Hongzhao; Yang, Lijun; Shan, Peipei; Zhu, Sujie; Ding, Han; Xue, Sheng; Wang, Yin; Yuan, Xubo; Li, Peifeng

doi:10.3390/pharmaceutics12020115

Cited by 16 publications

(10 citation statements)

References 44 publications

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“…During blend electrospinning, organic and sometimes highly toxic solvents are commonly used and may affect structure, stability and activity of the drug. Therefore, co-axial and emulsion electrospinning provide an alternative, where the drug can be dissolved in a more favorable solvent [ 20 , 21 , 22 , 23 ]. Nevertheless, all of these techniques involve high voltage, which may potentially damage the therapeutic agent [ 22 , 23 ].…”

Section: Wound Healing and Electrospun Wound Dressingsmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

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With the growth of the aging population worldwide, chronic wounds represent an increasing burden to healthcare systems. Wound healing is complex and not only affected by the patient’s physiological conditions, but also by bacterial infections and inflammation, which delay wound closure and re-epithelialization. In recent years, there has been a growing interest for electrospun polymeric wound dressings with fiber diameters in the nano- and micrometer range. Such wound dressings display a number of properties, which support and accelerate wound healing. For instance, they provide physical and mechanical protection, exhibit a high surface area, allow gas exchange, are cytocompatible and biodegradable, resemble the structure of the native extracellular matrix, and deliver antibacterial agents locally into the wound. This review paper gives an overview on cytocompatible and biodegradable fibrous wound dressings obtained by electrospinning proteins and peptides of animal and plant origin in recent years. Focus is placed on the requirements for the fabrication of such drug delivery systems by electrospinning as well as their wound healing properties and therapeutic potential. Moreover, the incorporation of antimicrobial agents into the fibers or their attachment onto the fiber surface as well as their antimicrobial activity are discussed.

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Section: Wound Healing and Electrospun Wound Dressingsmentioning

confidence: 99%

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Akhmetova

Heinz

2020

Pharmaceutics

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“…Besides, modulating the releasing behavior of nanoparticles is also a key point to the biocompatibility of nano-ZnO modified Ti materials. The utilization of functional coatings [e.g., polydopamine (PDA), chitosan, and poly(lactic-co-glycolic acid) (PLGA)] enables effective regulation, which can mostly be attributed to physical blocking, ion chelation, and antioxidant effects [ 52 , 65 , 76 , 90 ]. These results suggest that the nano-ZnO modification on Ti holds promise for clinical use, but the potential toxicity risks still remain to be minimized by innovative design.…”

Section: Fabrication Of Nano-zno Modified Ti Materials and Their Biosafe Propertiesmentioning

confidence: 99%

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Wang

et al. 2021

J Nanobiotechnol

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Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed. Graphical Abstract

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“…16,[22][23][24][25][26] Accumulating studies report that tiRNAs, which may have potential biological functions, are abnormally expressed or participate in the regulation of certain diseases, such as cancer, neurological, metabolic, and viral infectious diseases. [26][27][28][29][30] Notably, recent studies reveal that 5 0 -tiRNA is involved in regulating the proliferation and migration of cancer cells 31 and that 5 0 -tiRNA-Cys-GCA may be a biomarker of ischemia-reperfusion cell damage and death. 32 However, the relationship between 5 0 -tiRNA and cardiovascular diseases and whether 5 0 -tiRNA-Cys-GCA participate in the regulation of AD by altering the VSMC functions, such as proliferation and migration, are still unknown.…”

Section: Introductionmentioning

confidence: 99%

5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

Zong

Yang

Lin

et al. 2021

Molecular Therapy - Nucleic Acids

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Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) are still unknown. In this study, we found that 5 0 -tiRNA-Cys-GCA was significantly downregulated in human and mouse models of aortic dissection. The abnormal proliferation, migration, and phenotypic transition of vascular smooth muscle cells (VSMCs) played a crucial role in the initiation and progression of aortic dissection, with 5 0 -tiRNA-Cys-GCA as a potential phenotypic switching regulator, because its overexpression inhibited the proliferation and migration of VSMCs and increased the expression of contractile markers. In addition, we verified that signal transducer and activator of transcription 4 (STAT4) was a direct downstream target of 5 0 -tiRNA-Cys-GCA. We found that the STAT4 upregulation in oxidized low-density lipoprotein (ox-LDL)-treated VSMCs, which promoted cell proliferation, migration, and phenotypic transformation, was reversed by 5 0 -tiRNA-Cys-GCA. Furthermore, 5 0 -tiRNA-Cys-GCA treatment reduced the incidence and prevented the malignant process of angiotensin II-and b-aminopropionitrile-induced AD in mice. In conclusion, our findings reveal that 5 0 -tiRNA-Cys-GCA is a potential regulator of the AD pathological process via the STAT4 signaling pathway, providing a novel clinical target for the development of future treatment strategies for aortic dissection.

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The Stability Maintenance of Protein Drugs in Organic Coatings Based on Nanogels

Cited by 16 publications

References 44 publications

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

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