The state of receptor-dependent signal pathways in the agranulocytes from the peripheral blood of the reconvalescent patients following community-acquired pneumonia under the influence of microwave radiation

Терехов, И.; Бондарь, С С; Хадарцев, А. А.

doi:10.17116/kurort2016323-28

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…An important result of the action of resonant radiation on the cell, being in a state of transition to normal function, is an increasing trend to the restoration of its normal reactivity that allows us to characterize the effect of the microwave at 1 GHz as sanogenetic and harmonizing [11, 17, 25, 34]. …”

Section: Resultsmentioning

confidence: 99%

“…However, the states of these mechanisms in the postclinical stages of pathological processes and their role in the sanogenetic program realization have been insufficiently investigated [6, 11]. …”

Section: Introductionmentioning

confidence: 99%

“…Particularly sensitive to the action of a variety of unfavorable factors, including EMR, are organisms located in the nonstationary conditions, i.e. in conditions of transition from the state of health to the state of disease, or vice versa [11, 13]. …”

Section: Introductionmentioning

confidence: 99%

“…It provides restoration of the broken structure of the water media in the process of metabolic activity of cells accompanied by normalization of molecular, biochemical, and morphological changes characteristic of various pathological processes [15-19]. In this regard, the universally recognized role of microwaves used in the integrative approach to identify and refine the mechanisms of regulation of such conditions as tumor transformation, inflammation, apoptosis and autophagy, and aging should be noted [11-15]. In this case, the choice of the subject of our study, in particular the study of the features of the influence of low-intensity microwaves at a frequency of 1 GHz on cells is due to the resonance nature of the interaction of radiation with intracellular molecular targets localized in the aqueous phase.…”

Section: Introductionmentioning

confidence: 99%

“…In this case, the choice of the subject of our study, in particular the study of the features of the influence of low-intensity microwaves at a frequency of 1 GHz on cells is due to the resonance nature of the interaction of radiation with intracellular molecular targets localized in the aqueous phase. Being one of the natural oscillation frequencies of water molecules, radiation at a frequency of 1 GHz contributes to the restoration of the structure of the water media, while normalizing the molecular, biochemical, and morphological changes in cellular metabolism [11, 14]. Currently, it is not known if other frequencies could be used in medical or biological research in the range of ultrahigh or ultrahigh frequencies, which differ in the resonant nature of the effect on water media [14, 17, 18].…”

Section: Introductionmentioning

confidence: 99%

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The State of Intracellular Molecular Regulators during the Reconvalescence of Community-Acquired Pneumonia under the Influence of Microwaves at 1 GHz

et al. 2018

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We evaluated the levels of protein p53, retinoblastoma protein (RB), β-catenin, SMAD2, protein kinases AKT and focal adhesion kinase (FAK), and transcription factor CREB using ELISA in mononuclear leukocytes of patients with community-acquired pneumonia on days 15–17 of the disease. The research results showed that the subclinical immune-inflammatory process was characterized by a higher content of β-catenin by 19.8%, CREB by 23.3%, RB protein by 14.7%, increased phosphorylation level of protein kinase FAK by 19.8%, АKТ1 at serine-473 by 65.6%, and RB by 13.7%. In the cells, there was a decrease in p53 of 15.7%, SMAD2 of 16.9%, and protein kinase АKТ1 of 31.2%. Three hours after 1-GHz microwave irradiation, MNCs displayed a statistically significant increase in their content of the p53 protein of 20.0‰, RB of 9.35‰, β-catenin of 10.9‰, protein kinase FAK of 10.0‰, and CREB of 8.55‰. A day after a single irradiation of the cultures of whole blood cells, in irradiated cells compared to nonirradiated control, we observed a statistically significant increase in the content of p53 of 24.2‰, β-catenin of 15.1‰, SMAD2 of 20.4‰, RB of 9.8‰, as well as a reduction of the initially elevated levels of protein kinase AKT1 of 25.1‰, its phosphorylated form at serine-473 of 16.5‰, and a decrease in the phosphorylated form of the transcription factor CREB at serine-133 of 4.1‰. The research results indicate that a low-intensity microwave frequency of 1 GHz can be considered as a factor in molecular immune rehabilitation in conditions of community-acquired pneumonia.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The State of Intracellular Molecular Regulators during the Reconvalescence of Community-Acquired Pneumonia under the Influence of Microwaves at 1 GHz

et al. 2018

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Correction of Immunoendocrine Disorders in Patients with Ischemic Heart Disease Using Low-intensity Microwave Therapy

2017

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Prediction of target genes in community-acquired pneumonia based on the bioinformatics method

Zuo¹,

Shen²,

Chen³

et al. 2023

J Thorac Dis

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Background To screen the related genes of community-acquired pneumonia (CAP) by bioinformatics technology, and to analyze the clinical value of key genes. Methods Gene chip data sets containing CAP patients and normal controls were screened from the Gene Expression Omnibus (GEO) database. The downregulated differentially expressed genes (DEGs) were screened using a gene expression analysis tool (GEO2R). Simultaneously, gene set enrichment analysis (GSEA) was used to explore the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and core genes related to CAP. The candidate genes were then intersected with the genes reported in Online Mendelian Inheritance in Man (OMIM), and the clinical value of these candidate genes was examined based on a literature search. Finally, the clinical data of the CAP patients were retrospectively analyzed. Detect the type of pathogenic bacteria in bronchial-alveolar lavage fluid (BALF) using metagenomics next-generation sequencing (mNGS) high throughput sequencing technology, and detect the expression of key genes through liquid based cell immunohistochemistry to analyze the correlation between pathogenic bacteria and key genes. Results Through the intersection of Venn diagrams, 175 co-expressed downregulated DEGs related to CAP were identified. A total of 4 candidate genes, including ICOS , IL7R , ITK , and ZAP70 , were obtained by constructing the protein mutual aid network and conducting a module analysis of the common differentially expressed genes. The core genes in the GSEA enrichment pathways were intersected with the CAP-related genes reported in the relevant literature retrieved from the OMIM database. In the Venn diagram, two genes that coexist with OMIM include IL7R and PIK3R1 . After considering our findings and the relevant literature, we determined that the key gene related to the occurrence and development of CAP was IL7R . The mNGS detected 13 kinds of bacteria, 4 kinds of fungi, and 2 kinds of viruses. Based on immunohistochemical results, it was found that there were relatively more bacteria detected in the IL7R high expression group. Conclusions The identification of the key gene IL7R and the related signaling pathways extend understanding of the pathogenesis of CAP and provide a theoretical basis for clinical targeted therapy research.

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The state of receptor-dependent signal pathways in the agranulocytes from the peripheral blood of the reconvalescent patients following community-acquired pneumonia under the influence of microwave radiation

Cited by 4 publications

References 12 publications

The State of Intracellular Molecular Regulators during the Reconvalescence of Community-Acquired Pneumonia under the Influence of Microwaves at 1 GHz

The State of Intracellular Molecular Regulators during the Reconvalescence of Community-Acquired Pneumonia under the Influence of Microwaves at 1 GHz

Correction of Immunoendocrine Disorders in Patients with Ischemic Heart Disease Using Low-intensity Microwave Therapy

Prediction of target genes in community-acquired pneumonia based on the bioinformatics method

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