The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials

Negrescu, Andreea-Mariana; Cîmpean, Anișoara

doi:10.3390/ma14061357

Cited by 24 publications

(28 citation statements)

References 295 publications

(411 reference statements)

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“…Since its first description 20 years ago, the concept of “osteoimmunology” has emerged as a field of study that unifies the complex interactions between bone biology and the immune system [ 121 , 122 , 123 , 124 ]. For instance, the study of bone pathologies, such as rheumatoid arthritis or osteoporosis, has shown us the great influence of the immune system on the function of bone-forming cells [ 122 ]. Both, skeletal and immune systems share several regulatory molecules, including cytokines, chemokines, receptors, and transcription factors.…”

Section: Discussionmentioning

confidence: 99%

The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis

Quispe-Salcedo

Ohshima

2021

JCM

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The dental pulp is a soft connective tissue of ectomesenchymal origin that harbors distinct cell populations, capable of interacting with each other to maintain the vitality of the tooth. After tooth injuries, a sequence of complex biological events takes place in the pulpal tissue to restore its homeostasis. The pulpal response begins with establishing an inflammatory reaction that leads to the formation of a matrix of reactionary or reparative dentin, according to the nature of the exogenous stimuli. Using several in vivo designs, antigen-presenting cells, including macrophages and dendritic cells (DCs), are identified in the pulpal tissue before tertiary dentin deposition under the afflicted area. However, the precise nature of this phenomenon and its relationship to inherent pulp cells are not yet clarified. This literature review aims to discuss the role of pulpal DCs and their relationship to progenitor/stem cells, odontoblasts or odontoblast-like cells, and other immunocompetent cells during physiological and pathological dentinogenesis. The concept of “dentin-pulp immunology” is proposed for understanding the crosstalk among these cell types after tooth injuries, and the possibility of immune-based therapies is introduced to accelerate pulpal healing after exogenous stimuli.

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Section: Discussionmentioning

confidence: 99%

The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis

Quispe-Salcedo

Ohshima

2021

JCM

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“…91 On the other hand, to stimulate new bone formation and modulate the immune response induced by ROS production, various natural anti-oxidants have been included in different biomaterials/scaffolds and, so far, have resulted in positive outcomes. 92 Yet another approach to positively modulate the immune/ inflammatory response in bone may be via localized pharmacological interventions. For instance, it was observed after 2 weeks of implantation in rat tibia that the early bone fixation, measured as pull out force, of Pamidronate-coated Ti-screws was improved by 28%.…”

Section: Strategies Focused On the Peri-implant Osteoimmunology Of Th...mentioning

confidence: 99%

Implications of considering peri‐implant bone loss a disease, a narrative review

Albrektsson

Tengvall

Amengual‐Peñafiel

et al. 2022

Clin Implant Dent Rel Res

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Background Peri‐implantitis has been suggested to cause significant increasing proportions of implant failure with increasing time. Purpose To assess whether implant failure rates in long term studies are matching the supposed high prevalence of peri‐implantitis. Material and Methods This paper is written as a narrative review of the long‐term clinical investigations available in the literature. Results Some implant systems have seen unacceptable marginal bone loss figures with time coupled to increased implant failure rates, resulting in the withdrawal of these systems. The reasons for such mishap are generally unknown, with the exception of one system failure that was found to be due to improper clinical handling. Modern, moderately rough implant systems have functioned excellently over 10–15 years of follow up with minor problems with marginal bone loss and implant failure rates within a few per cent. Machined implants have functioned adequately over 20–30 years of follow up. Implant failures occur predominantly during the first few years after implant placement. No significant increase of implant failures has been observed thereafter over 20–30 years of follow up. Over the years of our new millennium, scientific and technical advances have allowed the discovery of numerous molecular pathways and cellular interactions between the skeletal and immune system promoting the development of the interdisciplinary field called osteoimmunology. Nowadays, this knowledge has not only allowed the emergence of new etiologic paradigms for bone disease but also a new dynamic approach on the concept of osseointegration and MBL around oral implants, re‐evaluating our older disease oriented outlook. This facilitates at the same time the emergence of translational applications with immunological perspectives, scientific approaches based on omics sciences, and the beginning of an era of personalized dental implant therapy to improve the prognosis of oral implant treatment. Conclusions Oral implant systems have been found to function with very good clinical outcome over follow‐up times of 20–30 years. Registered implant failures have occurred predominantly during the first few years after implantation, and there has been no significant increase in late failures due to peri‐implantitis.

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“…Therefore, modifications of titanium with new biomaterials were popularly promoted to achieve better biological behaviors. Those new biomaterials generally could be divided into metal material with outstanding mechanical and osseointegration properties, and nonmetallic materials with very good biodegradability and biocompatibility [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium

Chen

Ying

et al. 2022

Molecules

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Peri-implantitis can lead to implant failure. In this study, curcumin (CUR) was modified onto the copper-bearing titanium alloy (Cu-Ti) with the assistance of polydopamine (PDA) in order to study the bone immune response and subsequent osteogenesis. FE-SEM, XPS and water contact angle were utilized to characterize the coating surface. Bone marrow mesenchymal stem cells (BMSCs) and macrophages were cultured separately and together onto the CUR modified Cu-Ti. Cell activity, expression of relative genes and proteins, cell migration ability, and fluorescence staining of cells were performed. CUR modification slightly increased the activation of M1-type and M2-type cells under physiological conditions. In the inflammation state, CUR inhibited the overexpression of M1 macrophages and induced M2-type differentiation. In addition, the modification itself could provoke the expression of osteoblastic-related genes of BMSCs, while promoting the osteogenic differentiation of BMSCs through the activation of macrophages in both physiological and inflammatory states. The BMSCs migration was increased, the expression of osteogenic-related genes and proteins was up-regulated, and alkaline phosphatase activity (ALP) was increased. Thus, the modification of CUR can promote the osteointegration effect of Cu-Ti by bone immunomodulation and may, in addition, improve the success rate of implants.

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The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials

Cited by 24 publications

References 295 publications

The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis

The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis

Implications of considering peri‐implant bone loss a disease, a narrative review

Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium

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