The coronavirus (COVID-19) pandemic first impacted Thailand in early 2020. The government imposed lockdown measures from April to May 2020 to control the spread of infection. Daily lifestyles then morphed into a so-called new normal in which activities were conducted at home and people avoided congregation in order to prevent the spread of an infectious disease. This study evaluated the long-term air quality improvement which resulted from the restrictions enforced on normal human activities in Thailand. The air quality index (AQI) of six criteria pollutants and health risk assessments were evaluated in four areas, including metropolitan, suburban, industrial, and tourism areas in Thailand. The results showed that, after the restriction measures, the overall AQI improved by 30%. The subindex of each pollutant (sub-AQI) of most pollutants significantly improved (by 30%) in metropolitan areas after human activities changed due to the implementation of lockdown measures. With regard to industrial and tourism areas, only the sub-AQI of traffic-related pollutants decreased (34%) while the sub-AQIs of other pollutants before and after lockdown were similar. However, the changes in human activities were not clearly related to air quality improvement in the suburban area. The overall hazard index (HI) after lockdown decreased by 23% because of the reduction of traffic-related pollutants. However, the HI value remained above the recommended limits for the health of the adult residents in all areas. Therefore, strict regulations to control other pollutant sources, such as industry and open burning, will also be necessary for air quality improvement in Thailand.