The status and challenges of replicating the mechanical properties of connective tissues using additive manufacturing

Abstract

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Biohybrid Bovine Bone Matrix for Controlled Release of Mesenchymal Stem/Stromal Cell Lyosecretome: A Device for Bone Regeneration

“…Synthetic materials, such as hydroxyapatite (HA), bioactive glasses, and β-tricalcium phosphate (TCP), are primarily proposed as they are similar to the bone mineral matrix [7], even if they do not have the same biological and mechanical properties compared with bone. In this regard, 3D printing applied to such materials has recently been proposed as an innovative technique for personalized bone substitute therapy, promoting translation to clinical practice [8,9]. On the other hand, animal-derived materials (xenografts) may provide structures similar to living tissues and induce specific cellular responses.…”

Porous tantalum structure integrated on Ti6Al4V base by Laser Powder Bed Fusion for enhanced bony-ingrowth implants: In vitro and in vivo validation

“…Well-modified mechanical properties are the primary prerequisite for composite metallic scaffolds. The primary obligation of orthopedic scaffolds is to substitute for the non-functioning bone and provide adequate mechanical support; therefore, manufactured scaffolds should possess mechanical characteristics comparable to those of the human bone [ 32 ]. In this study, the compressive strength of the newly developed scaffolds reached over 6 MPa, which was higher than that of human cancellous bone (2–5 MPa) and sufficient for mechanical support [ 33 , 34 ].…”

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

“…pore volume, interconnectivity and distribution) [153,154] (see Fig. 6) [155]. It has become very attractive in the biomedical field due to its cost-effectiveness, possibility to obtain personalized devices in relatively fast times and to process both composites and biomaterials.…”