The status of COVID-19 vaccines in India: A review

Jha, Deepak Kumar; Pranay, Kumar; Samiksha, None; Kumar, Amit; Yashvardhini, Niti

doi:10.1016/j.vacun.2023.04.003

Cited by 3 publications

(2 citation statements)

References 106 publications

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“…Then we tested the hypotheses that "There is a significant co-occurrence of symptoms in reporting side-effects, indicating that the tweets are more likely to contain multiple symptoms simultaneously". To test this hypothesis, we calculated the correlation between the symptoms using a Spearman's correlation coefficient, which is used to determine the relation between two sets of data [43], the formula is shown in (5). Where, p is the correlation coefficient, di is the difference between the ranks for each observation, and N is the sample size.…”

Section: ) Construct Co-occurrence Of the Symptomsmentioning

confidence: 99%

“…Including, BNT162 (Pfizer-BioNTech) developed by Pfizer and BioNTech, ChAdOx1 (AstraZeneca) developed by AstraZeneca and the Oxford Vaccine Group at the University of Oxford, mRNA 1273 (Moderna) by Moderna, and Ad26.COV2-S by Johnson & Johnson [4]. There are also other vaccines were authorized only in emergency cases namely, Sputnik V (Gamaleya) designed by Gamaleya in Russia, CoronaVac by Sinovac, BBIBP-CorV developed by Beijing Institute of Biological Products/Sinopharm, and COVAXIN (Bharat Biotech) developed by Indian pharmaceutical company Bharat Biotech in collaboration with Indian Council of Research (ICMR) and National Institute of Virology (NIV) [5].…”

Section: Introductionmentioning

confidence: 99%

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Detecting Reported Side Effects of COVID-19 Vaccines From Arabic Twitter (X) Data

Alhumayani,

Alhazmi

2024

IEEE Access

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Vaccines might potentially cause side effects as any other drugs, which need to be investigated and analyzed to identify the public safety concerns. The massive vaccination rollout against COVID-19 provoked discussion among people through social media platforms. Twitter (X), a popular social media platform, plays a significant role in disseminating information about COVID-19 vaccines and monitoring people's reports regarding vaccination side effects. The aim of this study is to mine Twitter (X) to identify self-reported side effects related to COVID-19 vaccines in Arabic language, compare their distribution among six vaccine types, and construct Arabic lexicon of symptoms. We collected the tweets posts in Arabic language after the distribution of COVID-19 vaccines, then we developed a workflow for identifying selfreport symptoms using biterm topic modeling (BTM) and support vector machine (SVM) to extract the symptoms then cluster them in groups based on their co-occurrence. A total of 51 symptoms were extracted from 65,387 tweets that were reported 148,324 times. We performed a more in-depth analysis to investigate the symptoms that tend to occur simultaneously. The results show that the symptoms that more likely to occur together may indicate to a particular connection. The findings suggested that the social media conversation can provide a comprehensive depiction of symptoms that may complement what identified in clinical studies.

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Section: ) Construct Co-occurrence Of the Symptomsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detecting Reported Side Effects of COVID-19 Vaccines From Arabic Twitter (X) Data

Alhumayani,

Alhazmi

2024

IEEE Access

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Spots on 1H‐Indazole Incorporation into Thiazole Moiety‐Hybrid Heterocycles, Strong Efficacy as Small Molecules with Antimicrobial, Antineoplastic Activity, and In‐Silico Studies

Dawoud,

El‐Gendi,

Lotfy

et al. 2024

ChemistrySelect

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Amidst the escalating cancer cases and the relentless spread of multidrug‐resistant microbes, the urgency for effective medication is undeniable. In this context, our lab's continuous efforts have led to a promising discovery. We have conducted an extensive study on a series of new heterocycles with an indazolylthiazole component, which holds great promise as antimicrobial and anticancer drugs. The bioactivity tests, conducted with meticulous methodology, have demonstrated that the synthesized compounds possess remarkable antibacterial activity against various pathogenic strains. In a controlled lab setting, we have observed that derivatives 9, 11, and 12a effectively induce apoptosis in HCT‐166 and Huh‐7 (liver carcinoma) cell lines. Among these, derivative 11 has shown the highest selectivity (SI=14.54±1.2 and 16.51±1.4) and the lowest IC50 value. These compounds also exhibit broad‐spectrum antimicrobial activity. The anticancer activity of the synthesized compounds has been computationally confirmed through molecular modeling using MOE software and pharmacokinetic studies. Most of the tested compounds have shown significant cytotoxic activity against tumor cell lines, with high safety against normal human cells, thereby paving the way for a hopeful and promising future of antimicrobial and anticancer drugs, with potential applications in [specific_application_1] and [specific_application_2].

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Should We Recommend Routine Revaccination Against COVID-19 to Our Cardiac Patients?

Patnaik

2024

Indian Journal of Clinical Cardiology

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A well-researched review on adult vaccinations by Dr Sudhir Sinha in this issue of IJCC prompted me to pen a few lines on the need for regular (? yearly) revaccinations against COVID-19, in view of the apparent fading away of the disease around us. The pandemic began in November 2019 and within 12 months, effective vaccines could be introduced which proved beneficial in reducing deaths and severity of disease significantly. Since their first use in mid-January, 2021, in India itself 94% population received 1 dose and 86% received a second dose due to a mega vaccination drive. 1 Due to the cumulative effect of vaccine-efficacy and immunity due to natural infection, the disease burden receded globally. Fortunately, the recent variants of COVID-19 are less virulent. People have thrown away the masks and forgotten social distancing; life is as usual like in prepandemic days everywhere. Now we are left with the dilemma of whether vaccines are still relevant in these changed conditions. If vaccines have to continue, whether the whole population has to receive booster doses on a regular basis like influenza vaccination, or should we protect the most vulnerable sub-sets.World Health Organization (WHO) has approved about 15 vaccines for emergency use like Pfizer/BioNTech, Oxford/ Astra Zeneca, Johnson and Johnson, Moderna, Covilo, Novavax, Covovax, Spikevax, Can Sino, Comirnaty, and CoronaVac in a short span. Their acceptance was fairly satisfactory for the first and second doses. After that, the vaccine hesitancy started with reports of a few adverse effects-some real and some unrelated. As cardiologists, we are keen to learn about the cardiac events following COVID vaccination. An elegant review of case reports by Paknahad et al. is worth reading. The most common cardiac event was myocarditis with an incidence of 1.62%. The majority of them had mRNA vaccines (Moderna & Pfizer). Men were more frequently affected especially after the second dose. Inactivated vaccines had the least incidence of cardiovascular events. A higher incidence of thrombotic thrombocytopenia and pulmonary emboli was noted after mRNA vaccines compared to other type of vaccines. These authors concluded that the public health and personal benefits of COVID-19 vaccinations outweigh the cardiac risk events. 2

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The status of COVID-19 vaccines in India: A review

Cited by 3 publications

References 106 publications

Detecting Reported Side Effects of COVID-19 Vaccines From Arabic Twitter (X) Data

Detecting Reported Side Effects of COVID-19 Vaccines From Arabic Twitter (X) Data

Spots on 1H‐Indazole Incorporation into Thiazole Moiety‐Hybrid Heterocycles, Strong Efficacy as Small Molecules with Antimicrobial, Antineoplastic Activity, and In‐Silico Studies

Should We Recommend Routine Revaccination Against COVID-19 to Our Cardiac Patients?

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