The Ste20 group kinases as regulators of MAP kinase cascades

SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration

“…Classified as a novel germinal center kinase (GCK-V), the human Sterile20-like kinase (SLK) is ubiquitously expressed in adult tissues and cell lines and has been shown to share extensive sequence homology with the lymphocyte oriented kinase (LOK; 74%) as well as the Xenopus polo-like kinase kinase 1 (xPLKK1; 72%) [68][69][70][71]. SLK is defined by a sequence of 1202 amino acids, with a predicted molecular mass of 147 kDa which in actual fact, translates to an electrophoretic mobility of 220 kDa on SDS-PAGE [70].…”

Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways

“…Since mitotic CDK1 inhibits cytokinesis and abscission (cell cleavage) in fungi and metazoans, these studies also suggested that the MEN/SIN controls not only mitotic exit (progression from anaphase to late telophase), but can also play a role in the regulation of cytokinesis and abscission. Intriguingly, the core signalling module of the MEN/SIN is composed of highly conserved members of the Ste20-like kinase family [12][13][14], the MOB co-activator protein family [15], the LATS/NDR kinase family [16,17], and the Cdc14 protein phosphatase family [18]. The MEN/SIN pathway is very highly conserved from yeast to humans, since human Cdc14 can even compensate for the loss of Cdc14 in budding and fission yeast [19,20].…”

Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily

“…It is a mammalian homolog of the budding yeast Ste20 kinase [20]. Mst1 is involved in a variety of cellular processes such as morphogenesis, motility, proliferation, stress response, and apoptosis [20][21][22]. Previous studies have revealed that Mst1 is cleaved by caspase-mediated proteolysis in response to apoptotic stimuli such as FasL treatment [23].…”