The stem cell transplant program in Pakistan—the first decade

Shamsi, Tahir; Hashmi, KhalilUllah; Adil, Salman Naseem; Ahmad, Parvez; Irfan, Mohammad; Raza, Shahid; Masood, Nehal; Shaikh, Usman; Satti, Tariq Mahmood; Farzana, Tasneem; Ansari, Saqib Hussain

doi:10.1038/bmt.2008.137

Cited by 55 publications

(62 citation statements)

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“…[3][4][5][6][7] According to the report in Israel, this was achieved for 80% of patients with Arabic origin and for 40% of Jewish patients in an Israeli donor search program. 5 High proportions of HLA-identical donors found by all search types (ie, range, 60% to 80%) have been reported for Saudi Arabia, Jordan, and Pakistan, 4,15,16 and the overall rate that we observed in our pediatric group (52%) was comparable. This may be explained by the high rate of consanguineous marriages in Middle Eastern countries (22% in Turkey).…”

Section: Discussionsupporting

confidence: 66%

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Kaya

Gönen²,

Çalışkan³

et al. 2019

Exp Clin Transplant

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Objectives: Allogeneic hematopoietic stem cell transplant is a life-saving treatment, but donor numbers in Turkey do not meet the increasing demand for this procedure. Here, our objectives were (1) to assess the frequency of HLA-matched related donors in the Turkish population and (2) to identify the HLA antigens and haplotypes that are most frequent in Turkey. Materials and Methods: The HLA genotypes of 841 consecutive recipients and 3071 family members were retrospectively reviewed. Results: Matched related donors were identified for 368/841 recipients (44%). Extended family donor searches were performed for 111/181 pediatric recipients (61%), with nonsibling matched related donors found for 23 patients (21%). Matched related donors were found for a significantly higher proportion of pediatric patients (52%) than adult patients (41%) (odds ratio of 2.5; 95% confidence interval, 1.9-4.1; P = .02). The percentage of pediatric versus adult patients with 3 or more siblings was 13% versus 46% (odds ratio of 5.6; 95% confidence interval, 3.6-8.5; P = .001). The most frequent HLA class I antigens at each locus were HLA-A*02 (20.2%), HLA-B*35 (19.5%), and HLA-C*07 (19.8%). The most frequent HLA class II antigens at each locus were HLA-DRB1*11 (21.6%) and HLA-DQB1*03 (40.2%). The most common 3-locus haplotypes were HLA-A*24 B*35 DRB1*11 (F:0.020) and HLA-A*01 B*08 DRB1*03 (F:0.015). When adult and pediatric groups were combined, the most common locus haplotypes were found in 43/345 sibling donors (12%) and in 7/23 nonsibling pediatric donors (30%) (odds ratio of 2.7; 95% confidence interval, 1.2-6.4; P = .02). Conclusions:The results indicate that, in Turkey, it can be beneficial to revise donor search algorithms to include an extended family donor search before an unrelated donor search. This type of search can be effective because of the HLA haplotype diversity in Turkey, the frequency of consanguinity, and the country's limited donor pool.

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Section: Discussionsupporting

confidence: 66%

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Kaya

Gönen²,

Çalışkan³

et al. 2019

Exp Clin Transplant

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“…Recent reports on HSCT from Asian countries suggest the progress of HSCT in this region. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] However, no comprehensive picture of the current state of HSCT in Asia has been obtained. The Asia-Pacific region consists of countries with various ethnic, economical and social backgrounds.…”

Section: Introductionmentioning

confidence: 99%

Hematopoietic SCT activity in Asia: a report from the Asia-Pacific Blood and Marrow Transplantation Group

Yoshimi

Suzuki

Atsuta

et al. 2010

Bone Marrow Transplant

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“…Stem cell transplantation has been established only for hematological disorders. Allogenic bone marrow transplant has been established for aplastic anemia, β-thalassemia and hematological malignancies like AML at various hospitals like Agha Khan Hospital, Bismillah Taqee Institute of Health Sciences and Armed Forces Bone Marrow Transplant Centre in Pakistan [39].…”

Section: Local Work Related To Regenerative Medicine In Pakistanmentioning

confidence: 99%

Stem Cells in Regenerative Medicine: Prospects and Pitfalls

Zehravi¹,

Shahid²,

Kashmala³

et al. 2017

Natl. j. health sci.

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Stem cells are the cells that have the ability to regenerate themselves and are able to differentiate into one or more specialized cell types. This unique property makes them a valuable source for in vitro disease modeling, drug designing, regenerative medicine and tissue engineering. As no specie can fully mimic the human microenvironment, human cell models derived from patients cells provide a fascinating avenue for enhancing our current understanding of the early molecular stages of various diseases followed by validating therapeutics. In this paper, we reviewed the role of stem cells in regenerative medicine that includes use of cord blood derived stem cells in medicine and patient specific induced pluripotent stem cells for future transplant purposes and the hurdles and obstacles that we need to address before we can safely use these cells for patient cure.

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The stem cell transplant program in Pakistan—the first decade

Cited by 55 publications

References 1 publication

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

HLA Genotypes in Turkish Hematopoietic Cell Recipients and Likelihood of Finding a Matched Donor Through Family Searches

Hematopoietic SCT activity in Asia: a report from the Asia-Pacific Blood and Marrow Transplantation Group

Stem Cells in Regenerative Medicine: Prospects and Pitfalls

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