The Stereochemistry of Metal Chelates with Polydentate Ligands. Part I

Sarma, B. Das; Bailar, John C.

doi:10.1021/ja01626a007

Cited by 192 publications

(43 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…• C. Finally, at ∼ 760 • C, CuO is formed [37,38]. The probable structures of the present complexes are suggested as in Scheme 1.…”

Section: Thermal Studiesmentioning

confidence: 79%

“…The possibility of thione-thiol tautomerism (H−N− C=S) (C=N−SH) in these ligands has been ruled out for no bands around 2700-2500 cm −1 , characteristic of thiol group is displayed in the infrared absorption [37,38]. In far infrared region, the bands in 410-330 cm −1 are tentatively assigned to ν(Cu−N)/ν(Cu−S) (metal-ligand) stretching bands [39][40][41].…”

Section: Biological Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, Spectral and Biological Properties of Copper (Ii) Complexes of Thiosemicarbazones of Schiff Bases Derived From 4-Aminoantipyrine and Aromatic Aldehydes.

Agarwal¹,

Singh²,

Sharma³

2008

Reviews in Inorganic Chemistry

View full text Add to dashboard Cite

We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. . These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated.

show abstract

“…• C. Finally, at ∼ 760 • C, CuO is formed [37,38]. The probable structures of the present complexes are suggested as in Scheme 1.…”

Section: Thermal Studiesmentioning

confidence: 79%

Section: Biological Propertiesmentioning

confidence: 99%

Synthesis, Spectral and Biological Properties of Copper (Ii) Complexes of Thiosemicarbazones of Schiff Bases Derived From 4-Aminoantipyrine and Aromatic Aldehydes.

Agarwal¹,

Singh²,

Sharma³

2008

Reviews in Inorganic Chemistry

View full text Add to dashboard Cite

show abstract

“…Formation of these metal(III) complexes from the ligands 1 ( Fig. 1) results in formation of racemic mixtures of stereoisomers (31,45).…”

Section: Resultsmentioning

confidence: 99%

Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes

Goldberg

Sharma²,

Oksman

et al. 1997

Journal of Biological Chemistry

View full text Add to dashboard Cite

The malaria organism Plasmodium falciparum detoxifies heme released during degradation of host erythrocyte hemoglobin by sequestering it within the parasite digestive vacuole as a polymer called hemozoin. Antimalarial agents such as chloroquine appear to work by interrupting the heme polymerization process, but their efficacy has been impaired by the emergence of drugresistant organisms. We report here the identification of a new class of antimalarial compounds, hexadentate ethyl- enediamine-N,N-bis[propyl(2-hydroxy-(R)-benzylimino)]-metal(III) complexes [(R)-ENBPI-M(III)] and a corresponding ((R)-benzylamino)] analog [(R)-ENBPA-M(III)], a group of lipophilic monocationic leads amenable to metallopharmaceutical development. Racemic mixtures of Al(III), Fe(III), or Ga(III) but not In(III) (R)-ENBPI met-allo-complexes killed intraerythrocytic malaria parasites in a stage-specific manner, the R ‫؍‬ 4,6-dimethoxy-substituted ENBPI Fe(III) complex being most potent (IC 50 ϳ1 M). Inhibiting both chloroquine-sensitive and -resistant parasites, potency of these imino complexes correlated in a free metal-independent manner with their ability to inhibit heme polymerization in vitro. In contrast, the reduced (amino) 3-MeO-ENBPA Ga(III) complex (MR045) was found to be selectively toxic to chloroquine-resistant parasites in a verapamil-insensitive manner. In 21 independent recombinant progeny of a genetic cross, susceptibility to this agent mapped in perfect linkage with the chloroquine resistance phenotype suggesting that a locus for 3-MeO-ENBPA Ga(III) susceptibility was located on the same 36-kilobase segment of chromosome 7 as the chloroquine resistance determinant. These compounds may be useful as novel probes of chloroquine resistance mechanisms and for antimalarial drug development.

show abstract

“…After that, the deligation process started at a temperature range of 250-450 °C. Finally, at ~ 516 °C, metal-oxide formation takes place [21].…”

Section: Thermal Analysesmentioning

confidence: 99%

Antimicrobial Activity and Spectral, Magnetic and Thermal Studies of Some Transition Metal Complexes of a Schiff Base Hydrazone Containing a Quinoline Moiety

Al-Shaalan¹

2007

Molecules

View full text Add to dashboard Cite

A series of new copper(II), cobalt(II), nickel(II), manganese(II), iron(III), and uranyl(VI) complexes of the Schiff base hydrazone 7-chloro-4-(benzylidenehydrazo)quinoline (HL) were prepared and characterized. The Schiff base behaves as a monobasic bidentate ligand. Mononuclear complexes with the general composition [ML 2 (Cl) m (H 2 O) 2 (OEt) n ]·xEtOH (M = Cu(II), Co(II), Ni(II), Mn(II), Fe(III) or UO 2 (VI); m and n = 0-1; x = 1-3) were obtained in the presence of Li(OH) as a deprotonating agent. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, infrared, electronic spectra, magnetic susceptibility and conductivity measurements. An octahedral geometry was suggested for all the complexes except the Cu(II) and UO 2 (VI) ones. The Cu(II) complex has a square-planar geometry distorted towards tetrahedral, while the UO 2 (VI) complex displays its favored heptacoordination. The Schiff base ligand, HL, and its complexes were tested against one strain Gram +ve bacteria (Staphylococcus aureus), Gram -ve bacteria (Escherichia coli), and Fungi (Candida albicans). The prepared metal complexes exhibited higher antibacterial activities than the parent ligand and their biopotency is discussed.

show abstract

The Stereochemistry of Metal Chelates with Polydentate Ligands. Part I

Cited by 192 publications

References 0 publications

Synthesis, Spectral and Biological Properties of Copper (Ii) Complexes of Thiosemicarbazones of Schiff Bases Derived From 4-Aminoantipyrine and Aromatic Aldehydes.

Synthesis, Spectral and Biological Properties of Copper (Ii) Complexes of Thiosemicarbazones of Schiff Bases Derived From 4-Aminoantipyrine and Aromatic Aldehydes.

Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes

Antimicrobial Activity and Spectral, Magnetic and Thermal Studies of Some Transition Metal Complexes of a Schiff Base Hydrazone Containing a Quinoline Moiety

Contact Info

Product

Resources

About