The stimulation of lysosomal enzyme secretion from human polymorphonuclear leucocytes by leukotriene B4

Rae, S.; Smith, M. J. H.

doi:10.1111/j.2042-7158.1981.tb13884.x

Cited by 86 publications

(25 citation statements)

References 9 publications

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“…In addition to effects on leucocyte adhesion and migration, LTB 4 stimulates secretion of superoxide anion and release of different granulae constituents from leucocytes [101,102]. Among effects of LTB 4 on inflammatory cells, it has been observed that LTB 4 may stimulate expression of low-affinity receptors for IgE on B-lymphocytes [103], and the secretion of IgM, IgG and IgE [103][104][105].…”

Section: Effects Of Leukotriene Bmentioning

confidence: 99%

Asthma and leukotrienes: antileukotrienes as novel anti‐asthmatic drugs

Claesson¹,

1999

Journal of Internal Medicine

101

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Section: Effects Of Leukotriene Bmentioning

confidence: 99%

Asthma and leukotrienes: antileukotrienes as novel anti‐asthmatic drugs

Claesson¹,

1999

Journal of Internal Medicine

101

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“…The cysteinyl leukotrienes (LT),' LTC4, LTD4, and LTE4, affect the tonus of the arterioles and the permeability of postcapillary venules, thereby causing endothelial contraction and macromolecular leakage (13)(14)(15)(16). The dihydroxylated LTB4, one of the most powerful chemotactic substances known, has been implicated in the process of leukocyte accumulation, adhesion to the microvascular endothelium, emigration from the blood stream at sites of inflammation (13,(17)(18)(19), degranulation, and release of lysosomal enzymes (20)(21)(22) as well as generation of oxygen radicals (22, 23).…”

Section: Introductionmentioning

confidence: 99%

Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster.

Lehr¹,

Guhlmann²,

Nölte³

et al. 1991

J. Clin. Invest.

209

120

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Leukotriene (LT)B4 promotes leukocyte chemotaxis and adhesion to the endothelium of postcapillary venules. The cysteinyl leukotrienes, LTC4, LTD4, and LTE4, elicit macromolecular leakage from this vessel segment. Both leukocyte adhesion to the endothelium and macromolecular leakage from postcapillary venules hallmark the microcirculatory failure after ischemia-reperfusion, suggesting a role of leukotrienes as mediators of ischemia-reperfusion ijury.Using the dorsal skinfold chamber model for intravital fluorescence microscopy of the microcirculation in striated muscle in awake hamsters and sequential RP-HPLC and RIA for leukotrienes, we demonstrate in this study that (a) the leukotrienes (LT)B4 and LTD4 elicit leukocyte/endothelium interaction and macromolecular leakage from postcapillary venules, respectively, that (b) leukotrienes accumulate in the tissue after ischemia and reperfusion, and that (c) selective inhibition of leukotriene biosynthesis (by MK-886) prevents both postischemic leukotriene accumulation and the microcirculatory changes after ischemia-reperfusion, while blocking of LTD4/E4 receptors (by MK-571) inhibits postischemic macromolecular leakage.These results demonstrate a key role of leukotrienes in ischemia-reperfusion injury in striated muscle in vivo. (J. Clin. Invest. 1991Invest. . 87:2036Invest. -2041.) Key words: intravital fluorescence microscopy* microcirculation * striated muscle * leukocyte/endothelium interaction * macromolecular leakage

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“…Neutrophils are rapidly mobilized, and their number and distribution throughout the body ensures that they are often the first leukocytes to encounter invading organisms. In addition to neutrophil recruitment, LTB 4 stimulates their phagocytic activity, the formation of reactive oxygen species (31), and the release of granular enzymes (32). Although we cannot overlook that an effective Ag-specific response could be involved, the activation of neutrophils is probably the main mechanism by which LTB 4 exerts its antiviral activity within the first days of the infection.…”

Section: Discussionmentioning

confidence: 99%

Leukotriene B4 Protects Latently Infected Mice against Murine Cytomegalovirus Reactivation following Allogeneic Transplantation

Gosselin

Borgeat

Flamand

2005

The Journal of Immunology

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Human CMV is often associated with transplant rejection and opportunistic infections such as pneumonia in immunosuppressed patients. Current anti-CMV therapies, although effective, show relatively high toxicity, which seriously limits their long-term use. In this study, we provide evidence that leukotriene B4 (LTB4) plays an important role in the fight against murine CMV (MCMV) infection in vivo. Intravenous administration of 50 and 500 ng/kg/day of LTB4 to mice infected with a lethal dose of MCMV significantly increases their survival (50 and 70%, respectively), compared with the placebo-treated group (10% of survival). In mice infected with a sublethal dose of MCMV and treated daily with 50 ng/kg/day of LTB4, the salivary gland viral loads were found to be reduced by 66% compared with the control group. Furthermore, using an allogeneic bone marrow transplantation mouse model, the frequency of MCMV reactivation from latently infected mice was much lower (38%) in LTB4 (500 ng/kg)-treated mice than in the placebo-treated group (78%). Finally, in experiments using 5-lipoxygenase-deficient mice, MCMV viral loads in salivary glands were found to be higher in animals unable to produce leukotrienes than in the control groups, supporting a role of endogenous 5-lipoxygenase products, possibly LTB4, in host defense against CMV infection.

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The stimulation of lysosomal enzyme secretion from human polymorphonuclear leucocytes by leukotriene B4

Cited by 86 publications

References 9 publications

Asthma and leukotrienes: antileukotrienes as novel anti‐asthmatic drugs

Asthma and leukotrienes: antileukotrienes as novel anti‐asthmatic drugs

Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster.

Leukotriene B4 Protects Latently Infected Mice against Murine Cytomegalovirus Reactivation following Allogeneic Transplantation

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