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SummaryBehqet's disease is associated with vascular complications. Aortic regurgitation associated with this condition has never previously been described. A case is now reported in which this occurred and which was followed postoperatively by a false aneurysm of the ascending aorta. Case reportA 26-year-old man was referred to out-patients with severe leg ulceration in December 1974. He had had mouth and scrotal ulceration since the neonatal period and had observed that minor skin trauma was invariably followed by sepsis. He had no symptoms referable to the cardiovascular system and there was no past history of rheumatic fever.There was a positive family history in that his mother, brother and nephew all had episodes of mucocutaneous ulceration.He was thin and pale. There were no skeletal features of Marfan's syndrome. He had a single aphthous ulcer on his tongue and a symmetrical eruption over the extensor aspect of his lower limbs which comprised bluish papules and nodules; some hyperkeratotic and some pustular. Annular lichen planus was present at the base of the glans penis. In addition he had aortic regurgitation. BP was 140/50 mmHg.Investigations were: Hb, 14-7 g/dl; WBC, 9.9 x 109/1; ESR, 10 mm/hr; urea and electrolytes, normal; serum proteins and electrophoresis, normal; serological tests for syphilis, negative; chest X-ray, normal; metacarpo-phalangeal index, normal; sacroiliac joints, normal. Blood group, AB Rh-negative; tissue type: HLA A2.XB15.27/CW1. Skin biopsy showed non-specific epidermal reaction, dermal downgrowth and some degree of scarring. Immunofluorescence was negative.

COMMUNICATIONSadded to the medium in order to inhibit neuronal uptake only. As our study has shown cocaine to be a direct agonist at a-adrenoceptors and also to potentiate responses to acetylcholine by a postjunctional mechanism in the rat anococcygeus the use of cocaine in such studies with this tissue would seem inadvisable.