We consider the local well-posedness for 3-D quadratic semi-linear wave equations with radial data:It has been known that the problem is well-posed for s ≥ 2 and ill-posed for s < 3/2. In this paper, we prove unconditional well-posedness up to the scaling invariant regularity, that is to say, for s > 3/2 and thus fill the gap which was left open for many years. For the purpose, we also obtain a weighted fractional chain rule, which is of independent interest. Our method here also works for a class of nonlinear wave equations with general power type nonlinearities which contain the space-time derivatives of the unknown functions. In particular, we prove the Glassey conjecture in the radial case, with minimal regularity assumption.1.1. Quadratic semi-linear wave equation . In [19], by using bilinear estimates, together with standard energy-type estimates, Klainerman and Machedon proved the local well-posedness for the problem (1.1) with a + b = 0 (thus, satisfying the null condition) in H 2 , which was later improved to H s for s > s c , see [20], [21], [22] and references therein. Moreover, even without the null condition, their bilinear