The Structural Characterization of Oligonucleotide-Modified Gold Nanoparticle Networks Formed by DNA Hybridization*

Park, So‐Jung; Lazarides, Anne A.; Storhoff, James J.; Pesce, Lorenzo L.; Mirkina, Chad A.

doi:10.1201/9781003056690-23

Cited by 117 publications

(4 citation statements)

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“…Mirkin's initial work focused on exploring the linker DNA to hybridize the ssDNA−AuNP conjugates into macroscopic networks. 115 Mirkin and co-workers found that the interparticle distances in the assemblies were proportional to the length of the DNA linkers, 116,117 and significant correlation between the particle positions was only clear when the DNA linkers were double stranded. 117 These results indicate that the rigid core and multiple duplexed linkers (DNA bonds) together maintain the configuration of the nanoparticle-templated DNA assemblies.…”

Section: Nanoparticle-templated Dna Nanostructuresmentioning

confidence: 99%

DNA Nanotechnology-Enabled Drug Delivery Systems

et al. 2018

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Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function. Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nanomedicine. In this review, we begin with the origin of DNA nanotechnology, followed by summarizing state-of-the-art strategies for the construction of DNA nanostructures and drug payloads delivered by DNA nanovehicles. Further, we discuss the cellular fates of DNA nanostructures as well as challenges and opportunities for DNA nanostructure-based drug delivery.

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Section: Nanoparticle-templated Dna Nanostructuresmentioning

confidence: 99%

DNA Nanotechnology-Enabled Drug Delivery Systems

et al. 2018

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“…The fcc symmetry has the highest packing density of 74% for spherical particles and the highest coordination number of 12. Therefore, for the spherical particles which bind each other through an aldol reaction, the fcc symmetry provides the minimum system energy both entropically and enthalpically 28 . The distance between the nearest neighboring spherical Au NPs estimated from the lattice parameter is 28.1 nm.…”

Section: Characterization Of Au Npscs: Structures and Covalent Bondingmentioning

confidence: 99%

Highly Stable Nanoparticle Supercrystals Formed by the Aldol Reaction in Conjunction with Slow Solvent Evaporation

et al. 2022

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The nanoparticle supercrystals (NPSCs) have been of great interests for their collective emergent properties. While various NPSCs have been successfully fabricated using intermolecular forces, the limited structural stability of NPSCs due to the weak nature of the intermolecular forces still remains a major hurdle for practical applications. Herein, we report a new method to fabricate highly stable three-dimensional NPSCs by using aldol reaction, a model covalent bond forming reaction, in conjunction with slow solvent evaporation. Gold nanoparticles functionalized with thiol poly-ethylene glycol formyl are linked to each other by carbon-carbon covalent bonds formed by aldol reaction as the particle dispersion in aqueous NaOH solution is slowly evaporated, resulting in highly faceted three-dimensional NPSCs. Assynthesized NPSCs show excellent structural stability in solvents of different polartities as well as the dried condition and at temperature up to 160 °C, which is far superior to NPSCs stabilized by intermolecular forces such as hydrogen bonding and van der Waals interactions. The new covalent bonding appraoch opens up new opportunities in the synthesis of NPSCs and their applications.

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“…18 Recent studies have demonstrated the structural parameters of assembled DNA-mediated gold nanoparticle films can be regulated in a controllable manner by varying the length and sequence of DNA. 19,20 Zhou's group discovered that non-thiolated DNA can also be efficiently attached to GNPs to achieve high-stability spherical nucleic acid within minutes under a domestic microwave-assisted heating-dry circumstance. 21 Further, the nano-topographically patterns can also be readily controlled by altering the size and shape of gold nanoparticles.…”

Section: Introductionmentioning

confidence: 99%