The structure of aminoglycoside antibiotic 66-40G produced by Micromonospora inyoensis.

Micromonospora: A Prolific Source of Bioactive Secondary Metabolites with Therapeutic Potential

“…10 Recently, three sisomicin analogues (46−48) were successively identified from strain M. inyoensis NRRL 3292. 53,54 Feeding experiments in which 2,5-dideoxystreptamine was added to the culture broth of the M. inyoensis NRRL 3292 mutant resulted in the formation of a new compound, mutamicin 2 (51), which displayed remarkable activity against gentamicin-and sisomicin-resistant strains. 56 Verdamicin (52) was 1.5−3 times more active than gentamicin against both Gram-positive and Gram-negative bacteria, with the exception of Pseudomonas.…”

“…Compounds ( 45 – 52 ) belong to a subgroup of 2-deoxystreptamine-type AGs that are structurally close to gentamicin but have a double bond between C-4′ and C-5′ (Figure ). ,− Antibiotic 6640 ( 45 ), which was designated as a sisomicin analogue that was originally produced by M. inyoensis, was shown to possess an antibacterial spectrum similar to that of gentamicin and exhibit more potent bioactivities at pH values over 7 .…”