The structure of andrographolide

Choleretic action of andrographolide obtained from Andrographis paniculata in rats

“…The spectral data of andrographolide was in agreement with that reported by Cava et al (1962). The identity of andrographolide was further corroborated from the fragmentation pattern of its mass spectrum which exhibited the mass peak m / z at 332 and other significant fragment ions at 314,302,274,205,187,127,121,119,109,107,105,93.…”

“…Bhaduri (1914) isolated two bitter principles from A. paniculara known as kalmeghin and kalmeghic acid respectively. Kalmeghin was characterized as andrographolide by Cava et al (1962). Our present communication concerns the effects of andrographolide on liver function, especially on bile flow in albino rats.…”

Diastereoisomeric ent‐Labdane Diterpenoids from Andrographis paniculata

“…2). The absolute configuration of 1 was established on the basis of the configurations of andrographolide and isoandrographolide, which were confirmed by X-ray diffraction [15] [16] and ORD studies [17] [18]. Considering the biogenetic pathway of these diterpenoids, the configurations of C(3), C(4), C(5), C(9), and C(10) of 1 were determined as (R), (R), (S), (S), and (R), respectively.…”

Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions

“…31 The C-O stretching responses from the primary and the secondary alcoholic functions were recorded at 1,030 cm -1 and at 1,078 cm -1 . AG O-H stretching vibrations were recorded at 3,402 cm -1 , indicating an intermolecular hydrogen-bonded structure, and the O-H in-plane bending appeared at 1,420 cm -1 ( Figure 1A).…”