The structure of arenol and homoarenol, α-pyrone derivatives from (L.) moench

Medicinal Flowers. XXVII. New Flavanone and Chalcone Glycosides, Arenariumosides I, II, III, and IV, and Tumor Necrosis Factor-.ALPHA. Inhibitors from Everlasting, Flowers of Helichrysum arenarium

“…As the chemical constituents from this herbal medicine, several a-pyrones, flavonoids, chalcones, and phthalides were isolated from the flowers 3,4) and roots. 5,6) During the course of our characterization studies on medicinal flowers, 1,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] we found that the methanolic extract from the flowers of H. arenarium inhibited on tumor necrosis factor-a (TNF-a)-induced cytotoxicity in L929 cells.…”

“…25) From the methanolic extract, four new flavanone and chalcone glycosides named arenariumosides I (1), II (2), III (3), and IV (4) were isolated together with 46 known compounds [(5-49) and adenosine]. This paper deals with the isolation and structure elucidation of four new glycosides (1)(2)(3)(4) as well as effects of the principal constituents on TNF-a-induced cell death in L929 cells.…”

Arzanol, a Potent mPGES‐1 Inhibitor: Novel Anti‐Inflammatory Agent

“…Structure of arzanol is identical with homoarenol, (Figure 2(a)) which was isolated from H. arenarium L. Moench species [19]. Appendino et al [15] derived the name “arzanol” on the basis of plant H. italicum collected from Sardinian village—Arzana.…”

New flavanone and other constituents of Helichrysum arenarium indigenous to China

“…It was found that the characteristic secondary metabolites of everlasting are isoprenoids (mono-, sesqui-, di-, and triterpenoids) and phenolic compounds (aromatic phenols and acids, coumarins, phthalides, flavonoids, etc.) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].It is well known that the qualitative and quantitative compositions of plant secondary metabolites can change depending on the habitat and vegetation period. Studies of the chemistry of the H. arenarium population indigenous to China were begun because of this and due to its broad use in traditional Chinese medicine [21][22][23].…”

“…It was found that the characteristic secondary metabolites of everlasting are isoprenoids (mono-, sesqui-, di-, and triterpenoids) and phenolic compounds (aromatic phenols and acids, coumarins, phthalides, flavonoids, etc.) [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”