The structure of chloramphenicol

Acharya, Kriti; Gowda, D. S. Sake; Post, Michael L.

doi:10.1107/s0567740879006452

Cited by 14 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The configuration about the carbon is, however, planar. Such dissymmetry is also observed in chloramphenicol (Ravindra Acharya et al, 1979).…”

Section: Discussionsupporting

confidence: 55%

“…The slight widening in the endocyclic angle in the phenyl ring ipso to the nitro group is obviously an effect of the electron-withdrawing property of the latter. Such widening is also observed in chloramphenicol (Chatterjee et al, 1979;Ravindra Acharya et al, 1979), and in N-methyl-2,4,6-trinitroacetanilide (Christoph & Fleischer, 1973). The acetanilide side chain is in the extended conformation with C(8) trans to C(1) and O(1) cis to C(1), which is the usual geometry of the trans peptide linkage.…”

Section: Discussionmentioning

confidence: 76%

“…The shortening of the N(1)--C(7)single bond, similar to that observed in the peptide linkage (Marsh & Donohue, 1967), is also present in the chloramphenicol molecule (Ravindra Acharya, Sake Gowda & Post, 1979).…”

Section: Discussionmentioning

confidence: 77%

See 2 more Smart Citations

Structure of α,α-dichloro-4'-nitroacetanilide, C8H6Cl2N2O3

De¹,

Basak²,

Chaudhuri³

et al. 1984

Acta Crystallogr C

View full text Add to dashboard Cite

“…The configuration about the carbon is, however, planar. Such dissymmetry is also observed in chloramphenicol (Ravindra Acharya et al, 1979).…”

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 76%

See 1 more Smart Citation

Structure of α,α-dichloro-4'-nitroacetanilide, C8H6Cl2N2O3

De¹,

Basak²,

Chaudhuri³

et al. 1984

Acta Crystallogr C

View full text Add to dashboard Cite

“…Distinctive peaks associated with CAM were difficult to be observed due to the small drug load. Thus, only a small signal at 0.428 nm, which corresponds to the (401) and (114) reflections of the CAM structure, could be intuited [31].…”

Section: Resultsmentioning

confidence: 99%

Incorporation of Chloramphenicol Loaded Hydroxyapatite Nanoparticles into Polylactide

Rivas

Pelechà

Franco

et al. 2019

IJMS

View full text Add to dashboard Cite

Chloramphenicol (CAM) has been encapsulated into hydroxyapatite nanoparticles displaying different morphologies and crystallinities. The process was based on typical precipitation of solutions containing phosphate and calcium ions and the addition of CAM once the hydroxyapatite nuclei were formed. This procedure favored a disposition of the drug into the bulk parts of the nanoparticles and led to a fast release in aqueous media. Clear antibacterial activity was derived, being slightly higher for the amorphous samples due to their higher encapsulation efficiency. Polylactide (PLA) microfibers incorporating CAM encapsulated in hydroxyapatite nanoparticles were prepared by the electrospinning technique and under optimized conditions. Drug release experiments demonstrated that only a small percentage of the loaded CAM could be delivered to an aqueous PBS medium. This amount was enough to render an immediate bacteriostatic effect without causing a cytotoxic effect on osteoblast-like, fibroblasts, and epithelial cells. Therefore, the prepared scaffolds were able to retain CAM-loaded nanoparticles, being a reservoir that should allow a prolonged release depending on the polymer degradation rate. The studied system may have promising applications for the treatment of cancer since CAM has been proposed as a new antitumor drug.

show abstract

“…The increase in the C(7)-C(8) bond distance in the present structure compared to that in p-aminoacetophenone [ 1.498 (6)/k] can be explained as the effect of substitution at C(8). This lengthening is also observed in the structure of chloramphenicol which has similar substitution (Chatterjee et al, 1979;Ravindra Acharya et al, 1979).…”

Section: Cor-3441mentioning

confidence: 56%

Structure of 4'-amino-2,2,3'-trichloracetophenone, C8H6Cl3NO

De¹

1984

Acta Crystallogr C

View full text Add to dashboard Cite

The structure of chloramphenicol

Cited by 14 publications

References 4 publications

Structure of α,α-dichloro-4'-nitroacetanilide, C8H6Cl2N2O3

Structure of α,α-dichloro-4'-nitroacetanilide, C8H6Cl2N2O3

Incorporation of Chloramphenicol Loaded Hydroxyapatite Nanoparticles into Polylactide

Structure of 4'-amino-2,2,3'-trichloracetophenone, C8H6Cl3NO

Contact Info

Product

Resources

About