The Structure of Coenzyme A

Baddiley, J.

doi:10.1002/9780470122617.ch1

Cited by 14 publications

(4 citation statements)

References 71 publications

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“…The molecule consists of 3′‐phosphoadenosine coupled through the 5′ position of the ribose to pantothenic acid by a pyrophosphate linkage; the carboxyl end of pantothenic acid is linked through a peptidic linkage to β‐mercaptoethylamine …”

Section: Coenzyme Amentioning

confidence: 99%

Inborn errors of coenzyme A metabolism and neurodegeneration

Meo¹,

Carecchio

Tiranti³

2019

J of Inher Metab Disea

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Two inborn errors of coenzyme A (CoA) metabolism are responsible for distinct forms of neurodegeneration with brain iron accumulation (NBIA), a heterogeneous group of neurodegenerative diseases having as a common denominator iron accumulation mainly in the inner portion of globus pallidus. Pantothenate kinaseassociated neurodegeneration (PKAN), an autosomal recessive disorder with progressive impairment of movement, vision and cognition, is the most common form of NBIA and is caused by mutations in the pantothenate kinase 2 gene (PANK2), coding for a mitochondrial enzyme, which phosphorylates vitamin B5 in the first reaction of the CoA biosynthetic pathway. Another very rare but similar disorder, denominated CoPAN, is caused by mutations in coenzyme A synthase gene (COASY) coding for a bi-functional mitochondrial enzyme, which catalyzes the final steps of CoA biosynthesis. It still remains a mystery why dysfunctions in CoA synthesis lead to neurodegeneration and iron accumulation in specific brain regions, but it is now evident that CoA metabolism plays a crucial role in the normal functioning and metabolism of the nervous system. | COENZYME ACoA, described for the first time in 1945, 1 is an essential metabolic cofactor found in all living organisms that functions as an acyl group carrier and carbonyl-activating group in a

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Section: Coenzyme Amentioning

confidence: 99%

Inborn errors of coenzyme A metabolism and neurodegeneration

Meo¹,

Carecchio

Tiranti³

2019

J of Inher Metab Disea

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“…Biyolojik öneme sahip Koenzim A (asetil CoA, vb.) en çok bilinen tiyoesterlerden biridir [15]. Ayrıca penisilin, vankomisin ve eritromisin gibi çeşitli doğal poliketid antibiyotiklerin biyosentezinin tiyol ester ara maddelerini içerdiği bilinmektedir [16][17].…”

Section: Introductionunclassified

Synthesis and characterization of some benzothioate derivatives and investigation of extractions with Cr3+, Co2+, Cu2+, Mn2+, Fe3+, Zn2+ ions

Çalışır

2022

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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The biological importance of thiol compounds has increased the interest in these compounds in recent years. Thioester, thioether and disulfide compounds obtained from thiol compounds selectively bind metals such as gold, silver, iron, mercury, cadmium, zinc. Therefore, the complexes obtained have many usage areas such as luminescence, solar cells and panels, catalyst systems, adsorbents, photovoltaic cells, etc. In this study, ortho/meta/para-chloro-aromatic benzothioate derivatives (L1-L3) containing disulfide bonds were synthesized by thioesterification reaction. Characterizations were carried out by FT-IR, 1 H-NMR, 13 C-NMR and LC-MS/MS techniques. The complexes of synthesized benzothioate derivatives and Cr 3+ , Co 2+ , Cu 2+ , Mn 2+ , Fe 3+ , Zn 2+ ions were determined by liquid-liquid extraction (dichloromethane:water (1:1)). Extraction equilibrium constants Kext, KD, Ext%, ΔG o ext values were determined. L1 and L2 ligand extracted the most Cr 3+ ion (Ext%: 47.84% and 78.96%, respectively), and L3 ligand extracted the most Fe 3+ ion (Ext%: 98.95%).

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“…Ліпман був нагороджений медаллю Карла Нойберга Американського товариства хіміків (1948), національною медаллю «За наукові досягнення» Національного наукового фонду (1966), а також мав нагороду Міда Джонсона Американської академії педіатрії (1948). Він був почесним членом багатьох наукових товариств і почесним доктором університетів Парижа, Марселя, Чикаго і Коненгагена [46][47][48][49][50].…”

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