The nonperturbative nature of inter-nucleon interactions is explored by varying the momentum cutoff of a two-nucleon potential. Conventional force models, which have large cutoffs, are nonperturbative because of strong short-range repulsion, the iterated tensor interaction, and the presence of bound or nearly-bound states. But for low-momentum interactions with cutoffs around 2 fm −1 , the softened potential combined with Pauli blocking leads to corrections in nuclear matter in the particleparticle channel that are well converged at second order in the potential, suggesting that perturbation theory can be used in place of Brueckner resummations. Calculations of nuclear matter using the low-momentum two-nucleon force V low k with a corresponding leading-order three-nucleon (3N) force from chiral effective field theory (EFT) exhibit nuclear binding in the Hartree-Fock approximation, and become less cutoff dependent with the inclusion of the dominant second-order contributions. The role of the 3N force is essential to obtain saturation, and the contribution to the total potential energy is compatible with EFT power-counting estimates.