The structure of the antibiotic ostreogrycin B3

Cox, Brodie; Eastwood, FW; Snell, B. K.; Todd, Lord

doi:10.1039/c29700001623

Cited by 7 publications

(1 citation statement)

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“…This remaining bias can be calculated till the first order, , analytically using cubic part of the Taylor expansion of near the true value of ξ (see e.g. Cox & Snell 1968; Firth 1993). These calculations involve quite bulky tensor algebra and are omitted here.…”

Section: Bias Reductionmentioning

confidence: 99%

Accounting for velocity jitter in planet search surveys

Baluev

2009

Monthly Notices of the Royal Astronomical Society

134

215

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The role of radial velocity (RV) jitter in extrasolar planet search surveys is discussed. Based on the maximum likelihood principle, improved statistical algorithms for RV fitting and period search are developed. These algorithms incorporate a built-in jitter determination, so that resulting estimations of planetary parameters account for this jitter automatically. This approach is applied to RV data for several extrasolar planetary systems. It is shown that many RV planet search surveys suffer from periodic systematic errors which increase effective RV jitter and can lead to erroneous conclusions. For instance, the planet candidate HD74156 d may be a false detection made due to annual systematic errors.Comment: 10 pages, 1 figure, 1 table; accepted to MNRAS; 4th version due to a few extra minor corrections in Sect.11 and Tab.

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Section: Bias Reductionmentioning

confidence: 99%

Accounting for velocity jitter in planet search surveys

Baluev

2009

Monthly Notices of the Royal Astronomical Society

134

215

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Mass spectra of staphylomycin S components and of related cyclodepsipeptide antibiotics

Compernolle

Vanderhaeghe

Janssen

1972

Org. Mass Spectrom.

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Abstract-The electron-impact induced fragmentation of staphylomycin S (I) and related cyclodepsipeptides (I1 to V) is mainly initiated by elimination of an azomethin molecule (R-CH=N-R), i.e. 1,2-dehydro-4-oxopiperidine for I and 11, 1,2-dehydr0-4-hydroxy-piperidine for 111 and IV, and an unknown hydroxy-l,2-dehydro-4-oxopiperidiiie for VI. Cyclic imino acids, e.g. a pipecolic acid derivative for I to IV and 4-hydroxyproline for etamycin (IX) preferentially trigger this reaction. Clearcut evidence for the amino acid sequence is given by the mass spectra of the linear peptides obtained from I, V and IX by alkaline hydrolysis of the lactone function and esterification of the carboxy group. THE ISOLATION and structure determination of staphyloniycin S (I), one of the components of the antibiotic staphylomycin, has been described ear1ier.l The identification of the amino acids and oligopeptides, obtained after total and partial hydrolysis, provided the structural features of this compound. The increasing importance that mass spectrometry has won in recent years in establishing the sequence of amino acids in peptides indicated an alternative means of reinvestigating the structure of staphylomycin S. Furthermore some naturally occurring modifications, both known (11) and unknown (V, VI) and two epimeric dihydro derivatives (111, IV) were available to assist in (i) assigning possible structures to the fragment ions and (ii) determining the utility of these fragmentations for structure elucidation of peptides related to I.

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Mikamycin

Tanaka¹

1975

Mechanism of Action of Antimicrobial and Antitumor Agents

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The structure of the antibiotic ostreogrycin B3

Cited by 7 publications

References 0 publications

Accounting for velocity jitter in planet search surveys

Accounting for velocity jitter in planet search surveys

Mass spectra of staphylomycin S components and of related cyclodepsipeptide antibiotics

Mikamycin

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