The study between the dynamics and the X-ray anatomy and regularizing effect of gallbladder on bile duct sphincter of the dog

Wei, Jing-Guo; Wang, Yaocheng; Liang, Guo-Min; Wang, Wei; Chen, Baoying; Xu, Jia-Kuan; Song, Liang

doi:10.3748/wjg.v9.i5.1014

Cited by 3 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Direct neural pathways couple the duodenum with the gallbladder and SO, and the SO with the gallbladder. Several surgical procedures,such as gastrectomy [9] , vagotomy [10] and cholecystectomy [11,12] have been known to alter SO motility by disrupting certain aspects of the innervations. Numerous reports described SO motility after transection or electrical stimulation of extrinsic nerves,such as the vagal and splanchnic nerves [13][14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Yuan²,

Cheng³

et al. 2003

WJG

View full text Add to dashboard Cite

AIM: Several neural and hormonal factors are known to affect motility of sphincter of Oddi (SO). The major roles of SO are to regulate the flow of bile and pancreatic juice into the duodenum and to prevent the reflux of duodenal contents into the biliary and pancreatic duct. After pancreas transplantation, graft SO was denervated and graft pancreatitis might have relations to SO motility. The motility of SO after canine pancreas transplantation with bladder drainage was investigated. METHODS:Normal canine SO manometry and pancreas graft SO manometry after pancreas transplantation with bladder drainage were performed in seven dogs respectively before and after cholecystokinin (CCK) administration. Data of SO basal pressure, contraction frequency, amplitude and motility index after transplantation and CCK administration were compared with that in controls and before CCK administration.RESULTS: SO showed regular contractions with a certain basal pressure in control dogs. After transplantation, the graft SO basal pressure and contraction frequency were higher than that in controls, but the amplitude decreased (P<0.01). There was no great difference in SO motility index. CCK administration could relax normal SO but stimulate graft SO after pancreas transplantation with bladder drainage. After CCK administration, SO basal pressure, frequency and motility index were increased significantly (P<0.05), in comparison with that before administration. The amplitude remained unchanged (P>0.05), in comparison with that before CCK administration. CONCLUSION:After auto-pancreas transplantation with bladder drainage, canine SO motility was inhibited. Basal pressure and frequency increased but amplitude decreased. CCK administration after transplantation had an inhibitory effect on canine SO instead of a relaxation effect observed in normal canine SO. This will increase the resistance of SO to the pancreatic juice flow and induce pancreatic juice stagnation and can not prevent reflux of urine and duodenal contents when the bladder pressure is increased to a certain extent, which may cause graft pancreatitis.Li GC, Yuan CH, Cheng Y, Liu YF. Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage.

show abstract

Section: Discussionmentioning

confidence: 99%

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Yuan²,

Cheng³

et al. 2003

WJG

View full text Add to dashboard Cite

show abstract

“…1 The sphincter of Oddi (SO) plays an important role in preventing the reflux of duodenal fluid, and regulating the bile duct pressure. 2 An increase in the bile duct pressure can lead to dysfunction of SO contractility, which is associated with cholestasis.…”

Section: Introductionmentioning

confidence: 99%

Expression and alteration of BK_Ca channels in the sphincter of Oddi's from rabbits with hypercholesterolemia

et al. 2017

View full text Add to dashboard Cite

This study aimed to investigate the expression and function of BK Ca channels in the Sphincter of Oddi (SO) in a rabbit model of hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into 2 groups: the control group was fed standard chow (n D 18) whereas the high-cholesterol group was fed cholesterol-enriched chow containing 1.5% cholesterol (n D 18). The serum cholesterol level was significantly greater in the HC groups than in the control group, but there was no significant difference in body weight between the control and HC groups. Although the total protein expression of BK Ca a-and b 1 -subunit was not significantly different between the control and HC groups, the Tyr-phosphorylation of BK Ca a-subunit was significantly decreased in the HC group than in the control group. In addition, hypercholesterolemia significantly increased Acetylcholine (ACh)-induced contraction of the SO rings. Pretreatment with 30 mM NS1619, a BK Ca channel agonist, significantly reduced ACh-induced contraction of the SO rings in HC rabbits. Moreover, pretreatment with 100 mM Na 3 OV 4 , a protein tyrosine phosphatase inhibitor, significantly reduced ACh-induced contraction of the SO rings in HC rabbits, whereas it significantly increased upon pretreating with 10 mM Genistein, a tyrosine kinase inhibitor. Whole-cell patch clamp recordings showed that BK Ca current density was significantly lower in SOSMCs from HC group than that from control group. Our findings suggest that hypercholesterolemia-induced downregulation of BK Ca channel, and Tyr-phosphorylation of BK Ca a-subunit may contribute to the hyperresponsiveness of the SO ring in HC rabbits.

show abstract

Effects of cholesterol on proliferation and functional protein expression in rabbit bile duct fibroblasts

Chen¹,

Wei²,

Wang³

et al. 2004

WJG

View full text Add to dashboard Cite

show abstract

The study between the dynamics and the X-ray anatomy and regularizing effect of gallbladder on bile duct sphincter of the dog

Cited by 3 publications

References 31 publications

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Expression and alteration of BK_Ca channels in the sphincter of Oddi's from rabbits with hypercholesterolemia

Effects of cholesterol on proliferation and functional protein expression in rabbit bile duct fibroblasts

Contact Info

Product

Resources

About

The study between the dynamics and the X-ray anatomy and regularizing effect of gallbladder on bile duct sphincter of the dog

Cited by 3 publications

References 31 publications

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Oddi sphincter function after canine auto-pancreas transplantation with bladder drainage

Expression and alteration of BKCa channels in the sphincter of Oddi's from rabbits with hypercholesterolemia

Effects of cholesterol on proliferation and functional protein expression in rabbit bile duct fibroblasts

Contact Info

Product

Resources

About

Expression and alteration of BK_Ca channels in the sphincter of Oddi's from rabbits with hypercholesterolemia