The Study of Aetiology of Chronic Obstructive Pulmonary Disease (COPD) in Non-Smokers

Mathew, Nisha; Xavier, Zone; Deshmukh, Ashish S; Deshmukh, Hafiz; Jadhav, Sunil; Kasat, Shivaprasad

doi:10.4172/2161-105x.1000304

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…12 Positive family history of COPD, Frequent respiratory infections were found significantly associated with COPD in our study similar to results reported by Mathew et al from their study carried out at Aurangabad, Maharashtra. 13 Similar findings reported by Garg et al from their study in Delhi. 14 Beherns et al reported that incidence of COPD more among obese and underweight subjects similar to findings of our study.…”

Section: Discussionsupporting

confidence: 81%

An epidemiological study of chronic obstructive pulmonary disease among 35 years and above rural population of Gurugram, Haryana

Aggarwal¹,

Deswal

Ray

et al. 2019

Int J Community Med Public Health

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Background: COPD is 4th leading cause of death worldwide and predicted to be third by 2030. In India, COPD accounts for 7% of deaths and 3% DALYs loss. Study was conducted to Find the prevalence & determinants of COPD among 35 years & above rural population of Gurugram, Haryana and also determine health seeking behavior & economic burden of COPD cases.Methods: The study was conducted among field practice area of PHC Garhi Harsaru for one year. A total of 1434 individuals 35 years and above of age found in 700 households among were selected by probability proportion to size (PPS) sampling methods. 115 cases detected as cases were matched with equal number of controls matching and Data analyzed.Results: Prevalence of COPD was 8.02 % among 35 years & above age group. Smoking, passive smoking, biomass fuel smoke exposure, occupational exposure to dust/smoke/gas /chemical vapors at work, frequent respiratory infections, family history of COPD were found important determinants of COPD (P<0.05). Physical activity and body mass index were not found significant contributor on multivariate logistic regression analysis. Among all COPD patients 87.83% seeks immediate medical help in case of any breathing discomfort. Annual economic burden on COPD case was found to be Rs 14804/-.Conclusions: Smoking, exposure to smoke/dusty /chemical vapors and family history of COPD are main determinant of COPD. Public health planners should concentrate to mitigate these causes.

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Section: Discussionsupporting

confidence: 81%

An epidemiological study of chronic obstructive pulmonary disease among 35 years and above rural population of Gurugram, Haryana

Aggarwal¹,

Deswal

Ray

et al. 2019

Int J Community Med Public Health

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“…Few studies reported that exposure to toxic gases in the workplace, grain dust in farms, and dust and fumes in factories, occupational exposures in coal Miners, hard-rock miners, tunnel workers, and concrete manufacturers was strongly associated with COPD. [2][3][4] In NHANES III, Behrendt identified several occupations like plastic, textile, rubber, and leather manufacture; transportation and trucking; manufacture of food products; automotive repair was associated with high prevalence of COPD. 12 In present study, amongst occupational exposure, maximum patients were cotton mill workers (33.33%) followed by exposure to silica (27.78%) and welding fumes (11.1%).…”

Section: Resultsmentioning

confidence: 99%

“…The smoke emitted from burning of biomass contains large number of pollutants: particulate matter of less than 10 μm in aerodynamic diameter, carbon monoxide, nitrogen dioxide, sulphur dioxide, formaldehyde, and polycyclic organic matter, including carcinogens (e.g., benzpyrene). 4,5 The chronic airflow limitation is due to a mixture of small airway disease (obstructive bronchiolitis) or parenchymal destruction (emphysema). The relative contributions of which vary from person to person.…”

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confidence: 99%

Etiology and clinical profile of COPD in non-smoker in urban area

Pazare

Mehta

2018

Int J Adv Med

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Background: Smoking is established as a causative risk factor for COPD as early as 1950. However, in the past decade it is shown that, other risk factors like indoor and outdoor air pollutants, workplace exposure to dust and fumes, poor nourishment and poor socioeconomic status are also associated with COPD. COPD is a disease associated poor quality of life due to recurrent exacerbations. Till to date focus has been on smoking as a risk factor for COPD, but other factors also need to be taken into consideration.Methods: Study was conducted in 60 eligible patients from urban area for a period of 18 months. Individual patient was asked detailed personal demographic data, respiratory symptoms, exposure to passive smoking, family history of COPD. Detailed physical examination including Anthropometric measurements and other relevant general and systemic examination was carried out. Biochemical investigations, ECG, Chest X-ray, CT chest, spirometry and 2D echocardiography were carried out in all patients.Results: The mean age of the patient was 65.7±7.95 with male preponderance. Common symptoms were dyspnea and cough and common signs were rhonchi and hyper resonance note on percussion. Common risk factors were indoor air pollution and low socioeconomic class. Most of the patients has hypoxia and hypercapnia. X-ray chest and CT chest showed hyperinflation, air trapping. Majority of patients had moderate FEV/FVC ratio on spirometry.Conclusions: Non-smoker COPD patients usually present in old age. Common presentation is dyspnea followed by cough and rhonchi on examination. Most common risk factor for non- smoker COPD is indoor air pollution, low socioeconomic class and cotton mill workers. Amongst indoor pollution, LPG, kerosene and wood are the risk factors for non-smokers COPD in urban population.

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“…Chronic obstructive pulmonary disease (COPD) is a typical, preventable and treatable disease, distinguished by persistent airflow limitation which is progressive and linked with an intensified chronic inflammatory response in the airways . Pulmonary hypertension (PH) is a clinically pertinent problem in COPD, owing to its high prevalence and the impact that it has on morbidity and mortality .…”

Section: Introductionmentioning

confidence: 99%

Can ADMA play a role in determining pulmonary hypertension related to chronic obstructive pulmonary disease?

Telo

Kırkıl

Kuluöztürk

et al. 2017

Clinical Respiratory J

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The mean age of patients was 69.21 ± 10.62, and 15 of these patients were females. There was no significant difference between the two COPD groups in terms of age and sex (P > .05). There was no difference in PaO , SaO , FEV and FEV /FVC values between the two COPD groups (P > .05). Serum ADMA levels were similar in the control and the COPD group (0.42 ± 0.13 vs 0.43 ± 0.15), but it was significantly higher in the COPD-PH group compared to the control and the COPD group (0.49 ± 0.14). A negative correlation was determined between serum ADMA levels and SaO levels (r = -.247, P = .028). A significant positive correlation observed between ADMA and systolic pulmonary artery pressure values (r = .627, P < .001) CONCLUSIONS: In conclusion, high levels of serum ADMA levels may be able to determine the presence of PH.

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The Study of Aetiology of Chronic Obstructive Pulmonary Disease (COPD) in Non-Smokers

Cited by 4 publications

References 10 publications

An epidemiological study of chronic obstructive pulmonary disease among 35 years and above rural population of Gurugram, Haryana

An epidemiological study of chronic obstructive pulmonary disease among 35 years and above rural population of Gurugram, Haryana

Etiology and clinical profile of COPD in non-smoker in urban area

Can ADMA play a role in determining pulmonary hypertension related to chronic obstructive pulmonary disease?

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