The study of antiphospholipid antibodies in recurrent pregnancy loss

Abstract

INTRODUCTIONAround 15% of clinically recognised pregnancies in women less than 35 years old result in spontaneous miscarriage.1 However recurrent pregnancy loss (RPL) is encountered in 5% of couples with two or more losses and in around 1-2% of couples with three or more losses. Results: A total of 56 patients of recurrent miscarriage with two or more prior pregnancy losses were considered. Out of the 56 patients, 23 patients were excluded as per the exclusion criteria and 33 patients were included in the present study. The mean age of the study group was 24.63 years (Range: 20-32 years). Overall, seven patients (21.21%) were seen to have positive antiphospholipid antibody titers amongst the 33 patients, with repeat testing done after 12 weeks to confirm the positivity. Five patients (15.15%) were positive for ACA antibody. Four (12.12%) patients were positive for LA and B2GP1 each. Two patients (6.06%) were positive for both LA and ACA antibodies. Two patients (6.06%) were positive for LA and B2GP1 antibodies and two other (6.06%) patients were positive for ACA and Antiβ2GP1Ab. There was a statistically significant association noticed between ACA positivity and POG at 1st pregnancy loss. However, the overall association of APLA positivity and POG at pregnancy loss was not statistically significant. Conclusions: There was a significant difference of POG at first pregnancy loss in ACA positive patients as compared to the ACA negative patients. However, when all the APLA positive patients were considered the difference was not statistically significant.

Estimation of lupus anticoagulant in women with recurrent miscarriages.

“…Understanding the intersection between pregnancy-related hypercoagulability and recurrent miscarriages is vital for effective clinical management and risk assessment. 3 Healthcare providers need to be vigilant in recognizing these interconnected factors to provide appropriate interventions and support for women experiencing recurrent pregnancy loss. This knowledge underscores the importance of multidisciplinary collaboration between obstetricians, hematologists, and reproductive specialists to optimize care and improve outcomes for affected individuals.…”