The study of Bacteriocin of Pseudomonas fluorescens and Citrus limon effects against Propionibacterium acnes and Staphylococcus epidermidis in acne patients

Ahmed, Mais E.

doi:10.1088/1742-6596/1003/1/012004

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…In one study, a Lactobacillus -fermented Chamaecyparis obtusa leaf extract was reported to have a great effect on inflammatory markers, such as IL-8, IL-1, and NF- κ B [ 28 ]. Also, previous studies reported that essential oil and juice could alleviate acne vulgaris based on their antibacterial effect [ 49 , 50 ]. In our study, results showed that bergamot essential oil, bergamot juice, sweet orange essential oil, and sweet orange juice could reduce the levels of IL-6, TNF- α , MMP-2, MMP-9, and especially IL-1 α , indicating that bergamot essential oil, bergamot juice, sweet orange essential oil, and sweet orange juice could improve acne vulgaris through alleviating inflammatory response and suppressing P. acnes in golden hamsters (Figures 4 and 5 ).…”

Section: Discussionmentioning

confidence: 99%

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Sun

Zhao

Zhang

et al. 2020

Mediators of Inflammation

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Acne vulgaris is one of the most common chronic inflammatory skin diseases. Bergamot and sweet orange are rich in nutritional and functional components, which exhibit antioxidant, anti-inflammatory, and antiapoptotic effect. The aim of this study was to evaluate the potential effect of bergamot and sweet orange (juice and essential oil) on acne vulgaris caused by excessive secretion of androgen. Eighty male golden hamsters were randomly divided into 10 groups and received low or high dose of bergamot and sweet orange juice and essential oil, physiological saline, and positive drugs for four weeks, respectively. Results showed that all interventions could improve acne vulgaris by reducing the growth rate of sebaceous gland spots, inhibiting TG accumulation, decreasing the release of inflammatory cytokines (notably reducing IL-1α levels), promoting apoptosis in the sebaceous gland, and decreasing the ratio of T/E2. Among them, bergamot and orange essential oil may have better effects (dose dependent) on alleviating acne vulgaris than the corresponding juice. In view of the large population of acne patients and the widespread use of sweet orange and bergamot, this study is likely to exert an extensive and far-reaching influence.

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Section: Discussionmentioning

confidence: 99%

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Sun

Zhao

Zhang

et al. 2020

Mediators of Inflammation

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“…Screening for crude VRSAcin agreed with [33], who showed that the antimicrobial activity disappears under different laboratory conditions, and this indicates that the existence of the indicator strains in culture may induce bacteriocin production. On the other hand, estimation effects of S-Pyocin bacteriocin activity on acne and fungi [34]. while other results showed Staphylococcus spp.…”

Section: Histopathologymentioning

confidence: 89%

Antibacterial and therapeutic effects of Vancomycin-resistant Staphylococcus aureus bacteriocin (VRSAcin) in treatment of VRSA skin infection in mice

qassam,

emad

2024

Preprint

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Vancomycin Staphylococcus aureus (VRSA) is a strain belonging to S. aureus that is considered the main cause of bacterial skin and soft tissue infections. It has acquired resistance to vancomycin and represents a therapeutic challenge. The current study aimed to compare the possible therapeutic effects of VRSA bacteriocin (VRSAcin) on the treatment of skin infection in mice compared with an antibiotic (linezolid). The results showed that from fifty swabs obtained from human skin wounds, only 30 samples were identified as Staphylococcus spp., and 20 samples of them were identified as VRSA strains. One isolate was selected for VRSAcin extraction depending on its antibiotic resistance using an antibiotic susceptibility test. The typical conditions for the production of VRSAcin include pH 7 and a temperature of 37°C for 48 hours. In mice, VRSA-contaminated wounds revealed severe tissue distraction and inflammation that extended to the hypodermis, while VRSA-treated skin showed mild changes and localized lesions to the epidermis and upper dermis. Linezolid-ointment-treated skin shows moderate to severe changes. In conclusion, VRSA strain infections in human burned skin were found to be more common than expected. In vivo studies in mice indicated that wounded skin infected with VRSA can be treated with VRSAcin as an antibacterial agent that promotes healing processes with obvious superiority to linezolid ointment.

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“…Th e unique properties of iron oxide nanoparticles (NPs), including their large surface area, superparamagnetism, surface-to-volume ratio, and ease of separation, have attracted a lot of attention . P. aeruginosa is a common environmental bacterium that can colonize a range of habitats (Danafar et al, 2018) including ones that have been contaminated by humans, like sewage, oil spills, swimming pools, and water contaminated by biocide water (Ahmed, 2018;Dwivedi, 2018). Effl ux pumps have evolved as a way for bacteria to interact with the environment (Sanz-García, 2022).…”

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confidence: 99%

Синергічний вплив гентаміцину та наночасток оксиду заліза на ген phzM синьогнійної палички

Ahmed,

Abdul Muhsin

2024

Mikrobiol. Z.

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The increased use of iron-containing nanoparticles and green synthesis nanoparticles is beneficial and less harmful to the environment and human health. Working antimicrobial peptide functions by inhibiting the virulence factor of Pseudomonas aeruginosa, which is the essential mechanism of drug resistance by possessing an efflux pump important virulent factor. The main aim of the research was to study the effects of synergistic action of gentamicin (GNT) and iron nanoparticles (IONps) to solve the problem of multidrug-resistant P. aeruginosa. Methods. The isolation and identification of multidrug-resistant P. aeruginosa from burns and wound infections were carried out using the VITEK 2 system, and the phzM genes were detected in all the strains. The effectiveness of IONps and their role in reducing phzM gene expression were investigated. Results. The characterization of IONps biologically manufactured using a wavelength spectrum UV-vis spectrophotometer (maximum peak at 600 nm) and tests of atomic force microscopy showed that their diameter reached 34 nm. An electron microscope examination revealed that the produced particles were spherical, indicating good homogeneity and quality of the IONps. The results showed significant down-regulation changes in phzM expression after treatment with GNT and IONps. The result of qRT-PCR in this study revealed that the fold change in the expression of the phzM gene was downregulated in response to the IONps (8µg/mL) + GNT (16µg/mL) combination. Conclusions. One of the justifications for using P. aeruginosa in preparing IONps is that this bacteria needs iron as a growth promoter, which helps in the formation of IONps. The inhibitory effect on the efflux pump gene expression may represent a potential strategy for controlling P. aeruginosa infections.

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The study of Bacteriocin of Pseudomonas fluorescens and Citrus limon effects against Propionibacterium acnes and Staphylococcus epidermidis in acne patients

Cited by 8 publications

References 6 publications

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Essential Oil and Juice from Bergamot and Sweet Orange Improve Acne Vulgaris Caused by Excessive Androgen Secretion

Antibacterial and therapeutic effects of Vancomycin-resistant Staphylococcus aureus bacteriocin (VRSAcin) in treatment of VRSA skin infection in mice

Синергічний вплив гентаміцину та наночасток оксиду заліза на ген phzM синьогнійної палички

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