The study of memory and executive dysfunction in patients infected with Helicobacter pylori

Rezvani, Farzaneh; Sayadnasiri, Mohammad; Rezaei, Omid

doi:10.1080/01616412.2017.1363349

Cited by 10 publications

(8 citation statements)

References 41 publications

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“…It was revealed by a prospective, longitudinal study that children with a history of bacterial meningitis were at greater risk of impairment in executive ability (Anderson et al, 2004). A study that employed a total 140 participants who were selected using purposive sampling from the patients within the age group of 18-60 years old at Tehran in 2016 found that Helicobacter pylori infection increases the prevalence of memory and executive dysfunction (Rezvani et al, 2017). To the best of our knowledge, our study is the first to demonstrate the corresponding associations of selected taxa with specific domains of cognitive functioning among hypertension patients.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Signatures Are Predictive of Cognitive Impairment in Hypertension Patients—A Cohort Study

Dong

et al. 2022

Front. Microbiol.

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Growing evidence has demonstrated that hypertension was associated with dysbiosis of intestinal flora. Since intestinal microbes could critically regulate neurofunction via the intestinal–brain axis, the study aimed to reveal the role and prediction value of intestinal flora alteration in hypertension-associated cognitive impairment. A cohort of 97 participants included 63 hypertension patients and 34 healthy controls. The structure of intestinal flora was analyzed by V3–V4 16S rRNA amplicon sequencing. The cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale, and 31 patients were considered to have cognitive impairment (MoCA < 26). Patients with cognitive impairment had considerable alterations in intestinal flora structure, composition, and function compared with normal-cognitive patients. In particular, the abundance of LPS-containing taxa (Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, and Escherichia–Shigella) and SCFA-producing taxon (Prevotella) significantly changed in cognition-impaired patients. Tax4Fun predication results showed downregulation of glycan biosynthesis and metabolism in hypertension patients with cognitive impairment. Additionally, the pathway was demonstrated to be significantly correlated with LPS-containing taxa (Proteobacteria, Gammaproteobacteria, Enterobacterales, Enterobacteriaceae, and Escherichia–Shigella) and SCFA-producing taxon Prevotella. Furthermore, the taxa-based multiple joint prediction model (9×) was demonstrated to have excellent diagnostic potential for cognitive impairment of hypertension patients (AUC = 0.944). The current study revealed the involvement of intestinal microbiota dysbiosis in cognition-impaired hypertension patients and provided an objective predictive index for this cognition disorder.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiome Signatures Are Predictive of Cognitive Impairment in Hypertension Patients—A Cohort Study

Dong

et al. 2022

Front. Microbiol.

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“…9 Regarding cognition, H. pylori status was associated with lower baseline performances as reported by previous cross-sectional studies. 7,8 Beyond baseline cognitive scores, this study prospectively examined the risk of incident dementia according to H. pylori status. During the 7-year follow-up, H. pylori-positive participants had an increased risk of dementia, independently of various dementia risk factors [HR = 1.70], the risk of AD being still stronger [HR = 2.85].…”

Section: Discussionmentioning

confidence: 99%

“…Even though H. pylori prevalence has tended to decrease these last decades, cross‐sectional studies hint toward a high prevalence of this infection in older adults with cognitive disorders 7–9 . Likewise, longitudinal studies report different rates of negative cognitive outcomes in H. pylori ‐positive individuals or those treated for the infection 10–12 .…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and incident risk of dementia: The AMI cohort

Hernández‐Ruiz,

Roubaud‐Baudron,

Von Campe

et al. 2024

J American Geriatrics Society

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BackgroundChronic infectious diseases are increasingly being considered as potential contributors to dementia risk. Among those infections, Helicobacter pylori, the main cause of chronic gastritis worldwide, has been suggested. As the prevalence of H. pylori infection has decreased, the main objective of this work was to reconsider the association between H. pylori infection and the risk of incident dementia, including Alzheimer's disease.MethodsProspective cohort of 689 older (≥65 years) agricultural workers from Southwest France. Descriptive and comparative analyses were performed according to H. pylori status determined by serology at baseline. The risk of incident dementia according to H. pylori status over a 7‐year follow‐up was explored by survival analyses: Kaplan–Meier curve and Cox proportional hazards models.ResultsTwo‐hundred (29.0%) participants were H. pylori‐positive at baseline. Compared to H. pylori‐negative participants, they showed worse cognitive performances at baseline. Eighty‐five incident dementia cases were diagnosed during the follow‐up period. After adjustment for age, sex, education, apolipoprotein ε4, and several cardiovascular risk factors, H. pylori remained associated with an increased risk of dementia (HR 1.70, 95% CI, 1.05–2.74). The risk was stronger for Alzheimer's disease (HR 2.85, 95% CI, 1.58–5.12).ConclusionsDespite an observed decrease in H. pylori infection prevalence, this study provides evidence for the association between H. pylori infection and dementia. These results should encourage further research on the mechanisms underlying the contribution of infectious diseases to pathological brain aging, especially the influence of gut inflammation on the brain.

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“…Except for many upper gastrointestinal diseases, some extragastric diseases are also associated with H. pylori infection, such as atherosclerosis (AS), nonalcoholic fatty liver disease (NAFLD), diabetes, obesity, Alzheimer's disease (AD), chronic obstructive pulmonary disease (COPD), skin diseases, and blood diseases. [8][9][10][11][12][13][14] In particular, H. pylori infection can affect the cardiovascular system, and there is a causal relationship between H. pylori infection and cardiovascular events. 15 The role of H. pylori infection in the development of AS and its clinical prognosis has received attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous researches consistently reported that H. pylori is considered a pathogenic factor for gastric cancer. Except for many upper gastrointestinal diseases, some extragastric diseases are also associated with H. pylori infection, such as atherosclerosis (AS), nonalcoholic fatty liver disease (NAFLD), diabetes, obesity, Alzheimer's disease (AD), chronic obstructive pulmonary disease (COPD), skin diseases, and blood diseases 8‐14 . In particular, H. pylori infection can affect the cardiovascular system, and there is a causal relationship between H. pylori infection and cardiovascular events 15…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles from helicobacter pylori‐infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

Qiang

Tian

et al. 2022

Helicobacter

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Background The role of H. pylori infection has been reported in various extragastric diseases, particularly, the correlation between H. pylori and atherosclerosis (AS) have received lots of attention. Some scholars demonstrated that the presence of H. pylori‐specific DNA in the sclerotic plaques of atheromatous patients provides biological evidences, with indicating that H. pylori infection is a potential factor of AS. However, the underlying mechanism of H. pylori or their products cross the epithelial barriers to enter the blood circulation remains unclear. Recent studies have shown that the extracellular vesicles (EVs) derived from H. pylori‐infected gastric epithelial cells encapsulated H. pylori virulence factor cytotoxin‐associated gene A (CagA) and existed in the blood samples of patients or mice, which indicating that they can carry CagA into the blood circulation. Based on these findings, some researchers proposed a hypothesis that H. pylori is involved in the pathogenesis of AS via EVs‐based mechanisms. In addition, outer membrane vesicles (OMVs) serve as transport vehicles to deliver H. pylori virulence factors to epithelial cells. It is necessary to discuss the role of H. pylori OMVs in the development of AS. Objectives This review will focus on the correlation between H. pylori infection and AS and tried to unveil the possible role of EVs from H. pylori‐infected cells and H. pylori OMVs in the pathogenesis of AS, with a view to providing help in refining our knowledge in this aspect. Methods All of information included in this review was retrieved from published studies on H. pylori infection in AS. Results H. pylori infection may be an atherosclerotic risk factor and drives researchers to reevaluate the role of H. pylori in the pathogenesis of AS. Some findings proposed a new hypothesis that H. pylori may be involved in the pathogenesis of AS through EVs‐based mechanisms. Besides EVs from H. pylori‐infected cells, whether H. pylori OMVs may play some role in the pathogenesis of AS is still remain unclear. Conclusion Existing epidemiological and clinical evidence had shown that there is a possible association between H. pylori and AS. However, except for the larger randomized controlled trials, more basic research about EVs from H. pylori‐infected cells and H. pylori OMVs is the need of the hour to unveil the possible role of H. pylori infection in the pathogenesis of AS.

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The study of memory and executive dysfunction in patients infected with Helicobacter pylori

Cited by 10 publications

References 41 publications

Gut Microbiome Signatures Are Predictive of Cognitive Impairment in Hypertension Patients—A Cohort Study

Gut Microbiome Signatures Are Predictive of Cognitive Impairment in Hypertension Patients—A Cohort Study

Association between Helicobacter pylori infection and incident risk of dementia: The AMI cohort

Extracellular vesicles from helicobacter pylori‐infected cells and helicobacter pylori outer membrane vesicles in atherosclerosis

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