The study of mucin histochemistry in benign and malignant lesions of prostate

Agrawal, Durgaprasad N; Zawar, M P; Deshpande, Nandkumar M; Sudhamani, S

doi:10.4103/0974-5009.126751

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…In case of adenocarcinoma 56.66% cases were positive for PAS. 11 Almost similar findings were found by Bastola and Talwar in 2014. They found 87.8% cases of NHP and 44.4% cases of adenocarcinoma were PAS positive.…”

Section: Figure 1: Age Distribution Of Study Population (N=50)supporting

confidence: 81%

“…They found 87.8% cases of NHP and 44.4% cases of adenocarcinoma were PAS positive. 11 In the present study, acid mucin was detected by Alcian blue staining. It was positive in 11 cases (44%) of adenocarcinoma out of total 25 cases.…”

Section: Figure 1: Age Distribution Of Study Population (N=50)mentioning

confidence: 57%

“…Agarwal et al found 46.66% cases and Khanna et al 66.67% cases of PCa were positive for acidic mucin and none of the cases were of NHP was positive for acid mucin. 11,14 Among different grade group of adenocarcinomas 100% cases were acid mucin positive in grade group 1. Where 85.7% in grade group 2, 50% in grade group 3 and 33.3% were Alcian blue positive in grade group 4.…”

Section: Figure 1: Age Distribution Of Study Population (N=50)mentioning

confidence: 99%

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Evaluation of mucin histochemistry in relation to p63 expression in nodular hyperplasia and adenocarcinoma of prostate

Sweety

Sultana²,

Islam³

et al. 2023

Int J Res Med Sci

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Background: Prostate cancer is a leading cause of death in men. Nodular hyperplasia and adenocarcinoma are common causes of prostatic enlargement. Diagnosis of these lesions on routine biopsies can be difficult for pathologists. Immunohistochemical stain p63 can help, but it is costly and not widely available. The present study aimed to evaluate the usefulness of mucin histochemistry in relation to p63 expression in differentiating nodular hyperplasia and adenocarcinoma of prostate. Methods: This study was conducted in the department of pathology at Dhaka medical college from July 2018 to June 2020. 50 cases of prostatic lesions (25 NHP and 25 adenocarcinoma) were examined using histomorphology. The sections were stained with periodic acid Schiff (PAS) to identify neutral mucins and Alcian blue (2.5 pH) to identify acidic mucins. Additionally, p63 antibody was used in immunohistochemistry. Results: NHP showed positivity for neutral mucin (96% with PAS stain) but not for acidic mucin (Alcian blue stain), while prostatic carcinoma showed positivity for both neutral mucin (28%) and acidic mucin (44%). The grade group 1 tumors of prostatic carcinoma showed 100% positivity for acid mucin, with a decrease in Alcian blue staining as the grade increased. P63 was positive in 100% of NHP cases and negative in 100% of prostatic carcinoma cases. Conclusions: Positivity for acidic mucins with Alcian blue stain can be a helpful diagnostic tool to differentiate well differentiated adenocarcinomas from benign lesions where facility for p63 immuno-stain is not available and poor people who cannot afford the cost of immunohistochemistry.

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Section: Figure 1: Age Distribution Of Study Population (N=50)supporting

confidence: 81%

Section: Figure 1: Age Distribution Of Study Population (N=50)mentioning

confidence: 57%

Section: Figure 1: Age Distribution Of Study Population (N=50)mentioning

confidence: 99%

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Evaluation of mucin histochemistry in relation to p63 expression in nodular hyperplasia and adenocarcinoma of prostate

Sweety

Sultana²,

Islam³

et al. 2023

Int J Res Med Sci

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“…Basophilic mucin can be a supporting criteria for cases of prostate adenocarcinoma. 20,21 Intraluminal crystalloids were first discovered in 1977 as intraluminal eosinophilic structures with varying sizes and geometric shapes such as needles, triangles, and hexagonal. The mechanism of intraluminal crystalloid formation is unknown, but references state that intraluminal crystalloid is the result of abnormal protein and mineral metabolism in both benign lesions and malignant prostate acini.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Clinicohistomorphology Profile of Atypical Prostate Gland and Diagnosis Benign Lesion or Prostate Adenocarcinoma

MZ¹,

B²

2023

MPI

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BackgroundAtypical prostate gland especially atypical small acinar proliferation (ASAP) is a histopathological diagnosis that requires a follow-up biopsy 3-6 months after the first biopsy, because 17-60% of cases potentially to be malignant. The varied clinical and histomorphological characteristics of the atypical prostate gland make it difficult to confirm the final diagnosis as a benign lesion or prostate adenocarcinoma. This study aims to describe clinicohistomorphological cases of atypical prostate gland at Anatomical Pathology Department FKUI/RSCM and to identify histomorphological features of the atypical prostate gland as benign lesions or prostate adenocarcinoma on immunohistochemistry diagnosis.MethodsA histopathological investigation of prostate gland cases with atypical nuclei was carried out in 2011-2021 from archives of Anatomical Pathology Department FKUI/RSCM. Clinical and histomorphological characteristics were assessed and categorized into benign lesions or prostate adenocarcinoma based on immunohistochemistry appearance.ResultsThere were 109 cases of atypical prostate gland, 49 of which met the inclusion and exclusion criteria and could be analyzed. Corpora amylacea was found in 11 cases (84.6%) in the benign lesion group, statistically significant (p-value 0.005). Intraluminal crystalloids were found in 4 cases (100%) in the prostate adenocarcinoma group with p-value 0.050, close to significant. Other clinicohistomorphological characteristics did not show a significant relationship both in benign lesions and prostate adenocarcinoma groups (p-value 0.05).Conclusion On histopathological examination of the atypical prostate gland that is difficult to re-biopsy, the discovery of corpora amylacea may lead to the diagnosis of a benign lesion, while the discovery of intraluminal crystalloids may lead to the diagnosis of prostate adenocarcinoma. The diagnosis must be supported by immunohistochemistry characteristics.

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Althea rosea seed extract ameliorates 1,2-dimethylhydrazine induced preneoplastic lesions in mouse model of colon cancer by modulating oxidative stress and inflammation

et al. 2020

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The study of mucin histochemistry in benign and malignant lesions of prostate

Cited by 3 publications

References 4 publications

Evaluation of mucin histochemistry in relation to p63 expression in nodular hyperplasia and adenocarcinoma of prostate

Evaluation of mucin histochemistry in relation to p63 expression in nodular hyperplasia and adenocarcinoma of prostate

Relationship between Clinicohistomorphology Profile of Atypical Prostate Gland and Diagnosis Benign Lesion or Prostate Adenocarcinoma

Althea rosea seed extract ameliorates 1,2-dimethylhydrazine induced preneoplastic lesions in mouse model of colon cancer by modulating oxidative stress and inflammation

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