Background: Addiction is one of the most prominent problems and the fourth leading crisis worldwide. In Iran, this issue is more complicated because of increasing young population in this country. Objectives: This study aimed to predict addiction susceptibility regarding students’ personality traits at Qazvin universities. Methods: In this cross-sectional study, 227 students from Qazvin universities were selected using the multistage random stratified sampling method. Data collection tools were demographic information form, Addiction Susceptibility questionnaire (ASQ), and NEO personality inventory. After collecting the required data, SPSS software version 21 was used to analyze the data by running variance analysis and paired sample t-test. Results: In this study, neuroticism (P = 0.031) and openness (P = 0.043) with regression coefficients of 0.584 and 0.586 had positive and significant effects on addiction susceptibility, respectively. In contrast, extraversion (P = 0.023), agreeableness (P = 0.038), and consciousness (P < 0.001) with regression coefficients of -0.639, -0.186, and -1.342 had negative and significant effects on addiction susceptibility, respectively. Conclusions: The findings revealed a significant relationship between personality traits and addiction susceptibility. Accordingly, the aforementioned psychological traits must be empathized in educational, preventive, and therapeutic programs so that the vulnerable groups, including students, would receive some help.