The Subcommissural Organ and Reissner's Fiber Complex

SCO-spondin, a glycoprotein of the subcommissural organ/reissner's fiber complex: Evidence of a potent activity on neuronal development in primary cell cultures

“…Molecular features of SCO-spondin as well as in vitro bioassays favour a complex developmental role for the SCO/RF complex, an activity that has long been suspected (see Meiniel et al, 1996, for a review). Nevertheless, the exact function of the SCO/RF complex in vivo remains to be determined.…”

“…The exact significance of the Subcommissural organ (SCO) and Reissner's fiber (RF) complex in the vertebrate brain has long remained an enigma in spite of a great deal of research (reviewed in Meiniel et al, 1996). The morphological and structural features of the SCO/RF complex are now well established in a variety of species as well as the specificity of its secretory products.…”

Biosynthesis and molecular biology of the secretory proteins of the subcommissural organ

“…The subcommissural organ (SCO) may be regarded as one of the most active secretory ependyma ( Fig. 1; Meiniel et al, 1996;Oksche, 1961Oksche, , 1962Oksche, , 1969Rodríguez et al, 1992Rodríguez et al, , 1998. The secretory proteins synthesized by the SCO are released into the CSF.…”

Effects of SCO-spondin thrombospondin type 1 repeats (TSR) in comparison to Reissner's fiber material on the differentiation of the B104 neuroblastoma cell line

“…SCO-spondin is a brain-secreted glycoprotein expressed specifically and early in the subcommissural organ (SCO) (Gobron et al , 2000, an ependymal differentiation located in the roof of the third ventricle at the entrance to the Sylvian aqueduct (Oksche et al 1993;Meiniel et al 1996). This protein is widely distributed in the central nervous system, either through a basal release toward the posterior commissure or an apical release into the cavity of the third ventricle.…”