2012
DOI: 10.1016/b978-0-12-394307-1.00002-3
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The Subcommissural Organ and the Development of the Posterior Commissure

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Cited by 24 publications
(22 citation statements)
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References 328 publications
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“…The subcommissural organ, a specialized neuroepithelium located at the dorsal midline underneath the posterior commissure, releases the subcommissural organ spondin, a large glycoprotein belonging to the thrombospondin superfamily that shares molecular domains with axonal path-finding molecules. The subcommissural organ is thought to be involved in the development of the posterior commissure (3,12). In our anatomical study, we observed the posterior commissure but we could not distinctly identify the subcommissural organ.…”
Section: Discussioncontrasting
confidence: 66%
See 1 more Smart Citation
“…The subcommissural organ, a specialized neuroepithelium located at the dorsal midline underneath the posterior commissure, releases the subcommissural organ spondin, a large glycoprotein belonging to the thrombospondin superfamily that shares molecular domains with axonal path-finding molecules. The subcommissural organ is thought to be involved in the development of the posterior commissure (3,12). In our anatomical study, we observed the posterior commissure but we could not distinctly identify the subcommissural organ.…”
Section: Discussioncontrasting
confidence: 66%
“…Some fibers are believed to be derived from the posterior part of the thalamus and from the superior colliculus and to continue directly to the medial longitudinal fasciculus. Fibers from the thalamic, pretectal, tectal region, fibers from the superior colliculus and the habenular nuclei are known to connect with the posterior commissure, but they have not been shown anatomically (3)(4)(5)12).…”
Section: Introductionmentioning
confidence: 99%
“…The following previous lines of evidence have led some authors to propose that SCO-spondin contributes to the PC development (Meiniel et al, 2008; Caprile et al, 2009; Hoyo-Becerra et al, 2010; Stanic et al, 2010; Grondona et al, 2012): (1) the concomitant formation of SCO and PC, (2) the similarity of SCO-spondin with other molecules involved in axonal guidance, (3) the early secretion of this protein toward the extracellular matrix surrounding the PC axons, and (4) in vitro experiments where the addition of SCO-spondin or peptides derived from its sequence increase neurite length and fasciculation. Here, we provide direct in vivo evidence that SCO-spondin is crucial for PC formation, as its loss of function either causes a marked decrease in the number of axons (animals with total inhibition), a moderate diminution in the number of axons (inhibition at the caudal region), or axonal defasciculation (animals with cephalic inhibition).…”
Section: Discussionmentioning
confidence: 99%
“…Its formation is closely linked to that of the posterior commissure, and there is evidence that the SCO is required for proper pathfinding of commissural axons (Grondona et al. ). Genes that specifically affect the SCO have not yet been discovered, but both SCO and pineal development are affected in Pax6 mutants (see above) (Estivill‐Torrus et al.…”
Section: The Subcommissural Organ (Sco)mentioning
confidence: 99%