The subiculum: a review of form, physiology and function

O’Mara, Shane M.; Commins, Seán; Anderson, Michael; Gigg, John

doi:10.1016/s0301-0082(00)00054-x

Cited by 259 publications

(200 citation statements)

References 106 publications

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“…Similarly, the subicular complex plays a pivotal role in seizure propagation in epilepsy (O'Mara et al, 2001). In the similar manner, thalamocortical and motor cortex coupling were increased in 15q13.3 mice, and spike discharges in idiopathic generalized epilepsy are related to these networks (Pittau and Vulliemoz, 2015).…”

Section: Nacha7r Activation Results In Ca2+ Influx and A Consequent Fmentioning

confidence: 99%

An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7

Gass

Weber‐Fahr

Sartorius

et al. 2016

European Neuropsychopharmacology

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Section: Nacha7r Activation Results In Ca2+ Influx and A Consequent Fmentioning

confidence: 99%

An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7

Gass

Weber‐Fahr

Sartorius

et al. 2016

European Neuropsychopharmacology

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“…Place cells are also found in the subiculum, and they fire in a direction and location specific manner to process the spatial information (Sharp, 1997(Sharp, , 1999. The subiculum, being a major output station of CA1 hippocampus, integrates and transfers the information to cortical structures (O'Mara, Commins, Anderson, & Gigg, 2001). Lesioning of the ventral subiculum alters the oscillating network events in CA1 hippocampus and entorhinal cortex (Laxmi, Meti, & Bindu, 2000).…”

Section: Discussionmentioning

confidence: 99%

Transplantation of hippocampal cell lines restore spatial learning in rats with ventral subicular lesions.

Jinkala¹,

Chakravarthy²,

Veena³

et al. 2009

Behavioral Neuroscience

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We have demonstrated in our previous studies that ventral subicular lesion induces neurodegeneration of the hippocampus and produces cognitive impairment in rats. In the present study, the efficacy of transplanted green fluorescent protein (GFP)-labeled hippocampal cell line (H3-GFP) cells in establishing functional recovery in ventral subicular lesioned rats has been evaluated. The survival of H3-GFP transplants and their ability to express trophic factors in vivo were also investigated. Adult male Wistar rats were subjected to selective lesioning of ventral subiculum and were transplanted with H3-GFP cells into the cornu ammonis 1 (CA1) hippocampus. The transplants settled mainly in the dentate gyrus and expressed neurotrophic factors, brain-derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF). The ventral subicular lesioned (VSL) rats with H3-GFP transplants showed enhanced expression of BDNF in the hippocampus and performed well in eight-arm radial maze and Morris water maze tasks. The VSL rats without hippocampal transplants continued to show cognitive impairment in task learning. The present study demonstrated the H3-GFP transplants mediated recovery of cognitive functions in VSL rats. Our study supports the notion of graft meditated host regeneration and functional recovery through trophic support, although these mechanisms require further investigation.

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“…As the major output structure of the hippocampus, the subiculum projects to the entorhinal cortex, perirhinal cortex, prefrontal cortex, anterior cingulate cortex, thalamus, hypothalamus, nucleus accumbens, and amygdala (S. M. O'Mara, Commins, Anderson, & Gigg, 2001;Witter & Groenewegen, 1990). Given the widespread interest in the function of the hippocampus proper (e.g., CA1 and CA3) and the interconnectivity of many cortical and subcortical structures with the subiculum, surprisingly little research has been conducted on the physiology, pharmacology, or function of the subiculum (S. O'Mara, 2005;S.…”

Section: Discussionmentioning

confidence: 99%

Dissociating ventral and dorsal subicular dopamine D₁ receptor involvement in instrumental learning, spontaneous motor behavior, and motivation.

Andrzejewski¹,

Spencer²,

Kelley³

2006

Behavioral Neuroscience

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A series of experiments investigating the role of dopamine D 1 receptors in the ventral subiculum (vSUB) and dorsal subiculum (dSUB), 2 subregions of the hippocampal formation, found that D 1 receptor antagonism (3.0 nmol/0.5 μl SCH-23390 bilaterally) in the vSUB impaired instrumental learning and performance, reduced break point in progressive ratio (PR) tests, and produced an intrasession decline in responding during test sessions, but had no effect on spontaneous motor or food-directed behavior. In contrast, D 1 receptor blockade in the dSUB had no effect on instrumental learning, performance, PR break point, or food-directed behavior, but reduced spontaneous motor behavior. These results suggest a dissociation between the vSUB and dSUB with respect to the role of dopamine in various aspects of motivated and motor behavior. Further, D 1 activation in the vSUB may be a critical component of motivational arousal associated with learned contextual cues.

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The subiculum: a review of form, physiology and function

Cited by 259 publications

References 106 publications

An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7

An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7

Transplantation of hippocampal cell lines restore spatial learning in rats with ventral subicular lesions.

Dissociating ventral and dorsal subicular dopamine D₁ receptor involvement in instrumental learning, spontaneous motor behavior, and motivation.

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