The submicron particles FORMULATION OF IONIC-GELATION SUBMICRON PARTICLES LOADING EXTRACT PAPAYA LEAVES (Carica papaya L.) WITH LACTIC ACID ISOLATES

Abstract

A study regarding ionic-gelation submicron particle of papaya leaves (Carica papaya L.) extract with lactic acid of weeds potentially for antidiarrhea has been conducted. Preparation of papaya leaves ethanolic extract and lactic acid isolate into particles was done by ionic gelation method. This study aimed to determine: the major compound of extract, the total quercertine of extract, the percent value of encapsulation efficiency of the optimum formula which was varied by (CaOH)2 of the three formulas, and physical properties of particles. Formula 1 was using (CaOH)2 of 12.5 gram; formula 2 (CaOH)2 of 17,5 gram; formula 3 (CaOH)2 of 22.5 gram. The results showed formula 1 as the optimum formula that has the highest %EE. The average %EE values ​​of F1; F2; F3 respectively were 80,82%; 80,41%; 80,31%. The results of particle characterization using the PSA in the optimum formula produced particle size values ​​with an average of 253.6 nm, PDI of 0.218, and zeta potential +8 mV respectively.

The Future of Carica papaya Leaf Extract as an Herbal Medicine Product

“…In cosmetics, black hair dyes and face masks can be made from papaya seeds [25] and leaves [26], respectively. In relation to pharmaceutical products, various studies have been conducted to formulate papaya products operating via various routes of administration, including oral [27], topical [28], and transdermal [29]. More specifically, most papaya-based products administered via the oral route were prepared in capsule and tablet dosage forms [30,31], but others, using the liposome delivery system [32] and selfnanoemulsion [33], were also formulated.…”