Introduction: Inconsistent COVID-19 policies have caused the government to experience a degradation in public trust. So, it is necessary to propose policy recommendations for controlling positive COVID-19 cases that receive support from various multi-sectoral areas. Method: This research was conducted in January-May 2023. This type of research is qualitative-exploratory, using case study methods through indepth interviews and literature studies of all informants. Sampling was purposive sampling. This research variable uses Patton and Sawicki's alternative policy criteria theory (1986). Results: The proposed policy recommendations are increasing COVID-19 vaccine coverage and surveillance for monitoring coronavirus mutations. The two policy recommendations have met technical feasibility because they have clear outcomes, where the outcome of vaccination is to establish herd immunity. In contrast, surveillance of coronavirus mutations has the outcome of analyzing the efficacy of the COVID-19 vaccine. From the economic and financial possibility side, a budget is available with the advantage of carrying out normal activities without any restrictions and efficiency in the health budget. Regarding political viability, the government supports the policy, does not violate the rules, and serves the community's needs. Regarding administrative operability, the government as the authorized party is considered to have adequate capability, organizational support, and institutional commitment. Conclusion: The policy recommendations proposed by policymakers and epidemiology experts are increasing COVID-19 vaccination coverage and monitoring surveillance of coronavirus mutations, and it is hoped that the South Sulawesi Provincial Government can consider the proposed policy recommendations.