2016
DOI: 10.1016/j.bbamcr.2016.03.028
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The Sumo protease Senp7 is required for proper neuronal differentiation

Abstract: Covalent attachment of the Small ubiquitin-like modifier (Sumo) polypeptide to proteins regulates many processes in the eukaryotic cell. In the nervous system, Sumo has been associated with the synapsis and with neurodegenerative diseases. However, its involvement in regulating neuronal differentiation remains largely unknown. Here we show that net Sumo deconjugation is observed during neurogenesis and that Sumo overexpression impairs this process. In an attempt to shed light on the underlying mechanisms, we h… Show more

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Cited by 25 publications
(22 citation statements)
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“…The roles of OR4C5, OR51B6, SENP7 and LRP1B in CRC have not been well studied. SENP7 is involved in neuronal differentiation, DNA repair and meiosis . OR51B6 might play a regulatory role in gamma‐globin gene expression .…”
Section: Resultsmentioning
confidence: 99%
“…The roles of OR4C5, OR51B6, SENP7 and LRP1B in CRC have not been well studied. SENP7 is involved in neuronal differentiation, DNA repair and meiosis . OR51B6 might play a regulatory role in gamma‐globin gene expression .…”
Section: Resultsmentioning
confidence: 99%
“…Neurodegenerative diseases often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in neurodegenerative disease occurrence and progression. Accumulating evidences demonstrate perturbations of neuronal SUMOylation contribute to numerous pathological conditions and neurological disorders [ 7 , 48 , 49 ].…”
Section: Protein Sumoylation Relates To Multiple Diseasesmentioning
confidence: 99%
“…These results suggest that the increase in free SUMO1 and decrease in SUMOylated SIRT1 may be associated with the occurrence of BPD. A previous study reported that the differentiation of multipotent stem cells into neurons was inhibited by overexpression of SUMO1 ( 25 ). It was speculated that SENP1 may have a function in the differentiation of AT2; thus, this was investigated by culturing AT2 cells in vitro .…”
Section: Discussionmentioning
confidence: 99%
“…Due to the significant difference in the protein expression quantity of free SUMO1 and conjugated SUMO1, the exposure time of conjugated SUMO1 (20 sec) was shorter than that of free SUMO1 (50 sec). Thus, they are typically shown separately in immunoblot bands ( 24 , 25 ). Semi-quantitative analysis was performed using LANE 1D software (Beijing Sage Creation Science Co., Ltd., Beijing, China).…”
Section: Methodsmentioning
confidence: 99%