The suppression of thymic stromal lymphopoietin expression by selenium

Moon, Phil‐Dong; Kim, Hyung-Min

doi:10.1007/s00726-011-1156-z

Cited by 12 publications

(4 citation statements)

References 30 publications

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“…IL-1β-converting enzyme (ICE), known as caspase-1, is a protease in converting inactive IL-1β to active [42], and is known to inhibit activation of apoptosis [43]. Selenium recently was reported capable of inhibiting caspase-1 activation [44], so as to suppress tumor angiogenesis [45]. We found that the treatment of selenium yeast truly can neutralize expression of IL-1β (Fig.…”

Section: Discussionmentioning

confidence: 98%

Reduction of Splenic Immunosuppressive Cells and Enhancement of Anti-Tumor Immunity by Synergy of Fish Oil and Selenium Yeast

Wang

Chan

et al. 2013

PLoS ONE

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Growing evidence has shown that regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) abnormally increase in cancer cachectic patients. Suppressions of Tregs and MDSCs may enhance anti-tumor immunity for cancer patients. Fish oil and selenium have been known to have many biological activities such as anti-inflammation and anti-oxidation. Whether fish oil and/or selenium have an additional effect on population of immunosuppressive cells in tumor-bearing hosts remained elusive and controversial. To gain insights into their roles on anti-tumor immunity, we studied the fish oil- and/or selenium-mediated tumor suppression and immunity on lung carcinoma, whereof cachexia develops. Advancement of cachexia in a murine lung cancer model manifested with such indicative symptoms as weight loss, chronic inflammation and disturbed immune functionality. The elevation of Tregs and MDSCs in spleens of tumor-bearing mice was positively correlated with tumor burdens. Consumption of either fish oil or selenium had little or no effect on the levels of Tregs and MDSCs. However, consumption of both fish oil and selenium together presented a synergistic effect-The population of Tregs and MDSCs decreased as opposed to increase of anti-tumor immunity when both fish oil and selenium were supplemented simultaneously, whereby losses of body weight and muscle/fat mass were alleviated significantly.

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Section: Discussionmentioning

confidence: 98%

Reduction of Splenic Immunosuppressive Cells and Enhancement of Anti-Tumor Immunity by Synergy of Fish Oil and Selenium Yeast

Wang

Chan

et al. 2013

PLoS ONE

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“…Western blot analysis. The supernatants of the homogenized liver tissues were prepared in a sample buffer [62.5 mM Tris hydrochloride (Tris-HCl), pH 6.8, 2% sodium dodecyl sulphate (SDS), 20% glycerol and 10% 2-mercaptoethanol], as previously described (28)(29)(30). The samples were heated at 95˚C for 5 min and briefly cooled on ice.…”

Section: Quantitative Polymerase Chain Reaction (Qpcr)mentioning

confidence: 99%

Cysteine induces longitudinal bone growth in mice by upregulating IGF-I

Moon

Kim

et al. 2015

International Journal of Molecular Medicine

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Cysteine (Cys) is known to exert various effects, such as antioxidant, antipancreatitic and antidiabetic effects. However, the effects of Cys on longitudinal bone growth have not been elucidate to date. Thus, the aim of the present study was to evaluate the effects of Cys on bone growth. Growth-plate thickness and bone parameters, such as bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), connectivity density (Conn.D) and total porosity were analyzed by means of micro-computed tomography (μCT). The levels of serum insulin-like growth factor-I (IGF-I) were measured by enzyme-linked immunosorbent assay (ELISA). Hepatic IGF-I mRNA expression was analyzed by quantitative polymerase chain reaction (qPCR). The phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) was investigated by western blot analysis. Our results revealed that Cys increased IGF-I mRNA expression in HepG2 cells. The thickness of the growth plates was increased following treatment with Cys. Moreover, BV/TV, Tb.Th, TbN, Conn.D and total porosity were improved following treatment with Cys. Hepatic IGF-I mRNA expression and serum IGF-I levels were increased by Cys. The levels of phosphorylated JAK2 and STAT5 were elevated by Cys. The findings of our study indicate that Cys increases the thickness of growth plates through the upregulation of IGF-I, which results from the phosphorylation of JAK2-STAT5. Thus, our data suggest that Cys may have potential for use as a growth-promoting agent.

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“…Total RNA was isolated from liver tissues using an easy‐BLUE™ RNA extraction kit (iNtRON Biotech, Republic of Korea) and quantitative real‐time PCR was performed using a SYBR Green master mix. mRNA was analyzed using an ABI StepOne real‐time PCR System (Applied Biosystems, Foster City, CA), as previously described .…”

Section: Methodsmentioning

confidence: 99%

Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

et al. 2015

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Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.

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The suppression of thymic stromal lymphopoietin expression by selenium

Cited by 12 publications

References 30 publications

Reduction of Splenic Immunosuppressive Cells and Enhancement of Anti-Tumor Immunity by Synergy of Fish Oil and Selenium Yeast

Reduction of Splenic Immunosuppressive Cells and Enhancement of Anti-Tumor Immunity by Synergy of Fish Oil and Selenium Yeast

Cysteine induces longitudinal bone growth in mice by upregulating IGF-I

Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

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