The supramedullary cells of the teleost Coris julis (L.): a noradrenergic neuronal system

Mola, Lucrezia; Sassi, D; Cuoghi, Barbara

doi:10.4081/1744

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cells appear to be responsible for the innervation of mucous gland cells in the integument of several teleost species (Mola et al . ; Mola and Coughi ; Funakoshi et al . ).…”

Section: Discussionmentioning

confidence: 98%

Confocal imaging and phylogenetic considerations of the subcutaneous neurons in the Atlantic hagfish Myxine glutinosa

Zaccone¹,

Fudge

Winegard

et al. 2014

Acta Zoologica

View full text Add to dashboard Cite

Zaccone, G., Fudge, D.S., Winegard, T.M., Capillo, G., Kuciel, M., Funakoshi, K. and Lauriano, E.R. 2015. Confocal imaging and phylogenetic considerations of the subcutaneous neurons in the Atlantic hagfish Myxine glutinosa. -Acta Zoologica (Stockholm) 96: 209-217.We used confocal microscopy and immunohistochemistry to characterize the morphology of the subcutaneous neurons and the innervation of the slime glands and striated muscles in the hagfish Myxine glutinosa. A rich plexus of 5HT-, ChAT-and TH-positive neurons is described in the capsule of the slime glands. These neurons, like those of the subcutaneous plexus, receive pericellular terminations from the axons of central cells. Capsular neurons receive innervation from 5HT-positive and nNOS-positive nerve fibres. Other nerve endings belonging to two separate nerve populations are identified in the striated muscles. They contain TH and nNOS immunoreactivity. Due to the lack of any topographical labelling, the cell origin and the projections of the neurons into the cranial and spinal nerves are unknown. This study provides anatomical evidence of multiple (5HT and nNOS) peripheral innervation of the neurons. However, it does not provide information about the function of these neurons in the hagfish. We suggest that hagfish neurons have a phylogenetic relationship with the spinal group of the dorsal cells of lampreys and the supramedullary cells of teleosts.

show abstract

“…These cells appear to be responsible for the innervation of mucous gland cells in the integument of several teleost species (Mola et al . ; Mola and Coughi ; Funakoshi et al . ).…”

Section: Discussionmentioning

confidence: 98%

Confocal imaging and phylogenetic considerations of the subcutaneous neurons in the Atlantic hagfish Myxine glutinosa

Zaccone¹,

Fudge

Winegard

et al. 2014

Acta Zoologica

View full text Add to dashboard Cite

show abstract

“…2). The functional role of the SN cluster in the puffer fish is probably the innervation of cutaneous mucous glands (Funakoshi et al 1998) and the presence of neurotransmitters such as noradrenaline indicate that the cluster is a component of the autonomic nervous system (Mola and Cuoghi 2004;Mola et al 2002). The morphology and spatial distribution of all cells, both SN and glial cells, belonging to the cluster and their relationships with each other have been studied in two puffer fish species, viz.…”

Section: Nomenclature Problemsmentioning

confidence: 99%

Macroglial cells of the teleost central nervous system: a survey of the main types

Cuoghi

Mola

2009

Cell Tissue Res

View full text Add to dashboard Cite

Following our previous review of teleost microglia, we focus here on the morphological and histochemical features of the three principal macroglia types in the teleost central nervous system (ependymal cells, astrocyte-like cells/radial glia and oligodendrocytes). This review is concerned with recent literature and not only provides insights into the various individual aspects of the different types of macroglial cells plus a comparison with mammalian glia, but also indicates the several potentials that the neural tissue of teleosts exhibits in neurobiological research. Indeed, some areas of the teleost brain are particularly suitable in terms of the establishment of a "simple" but complete research model (i.e. the visual pathway complex and the supramedullary neuron cluster in puffer fish). The relationships between neurons and glial cells are considered in fish, with the aim of providing an integrated picture of the complex ways in which neurons and glia communicate and collaborate in normal and injured neural tissues. The recent setting up of successful protocols for fish glia and mixed neuron-glia cultures, together with the molecular facilities offered by the knowledge of some teleost genomes, should allow consistent input towards the achievement of this aim.

show abstract

“…These neurons are very small in number, and have been proposed as a good in vivo model for electrophysiology studies due to their prominent size and convenient location. These large cells are thought to have a neuro-endocrine function as some species of puffer fish produce noradrenalin ( Mola et al, 2002 ; Mola and Cuoghi, 2004 ). The need for biosynthesis of large amounts of adrenaline may underlie the polyploidy in these cells, however, this has not been functionally tested.…”

Section: Are All Terminally Differentiated Neurons Permanently Diploid and In G0?mentioning

confidence: 99%

Cell Cycle Re-entry in the Nervous System: From Polyploidy to Neurodegeneration

Nandakumar

Rozich

Buttitta

2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Terminally differentiated cells of the nervous system have long been considered to be in a stable non-cycling state and are often considered to be permanently in G0. Exit from the cell cycle during development is often coincident with the differentiation of neurons, and is critical for neuronal function. But what happens in long lived postmitotic tissues that accumulate cell damage or suffer cell loss during aging? In other contexts, cells that are normally non-dividing or postmitotic can or re-enter the cell cycle and begin replicating their DNA to facilitate cellular growth in response to cell loss. This leads to a state called polyploidy, where cells contain multiple copies of the genome. A growing body of literature from several vertebrate and invertebrate model organisms has shown that polyploidy in the nervous system may be more common than previously appreciated and occurs under normal physiological conditions. Moreover, it has been found that neuronal polyploidization can play a protective role when cells are challenged with DNA damage or oxidative stress. By contrast, work over the last two and a half decades has discovered a link between cell-cycle reentry in neurons and several neurodegenerative conditions. In this context, neuronal cell cycle re-entry is widely considered to be aberrant and deleterious to neuronal health. In this review, we highlight historical and emerging reports of polyploidy in the nervous systems of various vertebrate and invertebrate organisms. We discuss the potential functions of polyploidization in the nervous system, particularly in the context of long-lived cells and age-associated polyploidization. Finally, we attempt to reconcile the seemingly disparate associations of neuronal polyploidy with both neurodegeneration and neuroprotection.

show abstract

The supramedullary cells of the teleost Coris julis (L.): a noradrenergic neuronal system

Cited by 7 publications

References 8 publications

Confocal imaging and phylogenetic considerations of the subcutaneous neurons in the Atlantic hagfish Myxine glutinosa

Confocal imaging and phylogenetic considerations of the subcutaneous neurons in the Atlantic hagfish Myxine glutinosa

Macroglial cells of the teleost central nervous system: a survey of the main types

Cell Cycle Re-entry in the Nervous System: From Polyploidy to Neurodegeneration

Contact Info

Product

Resources

About