Instrumenting a gigaton of ice at the geographic South Pole, the IceCube Neutrino Observatory has been at the forefront of groundbreaking scientific discoveries over the past decade. These include the observation of a flux of TeV-PeV astrophysical neutrinos, detection of the first astrophysical neutrino on the Glashow resonance and evidence of the blazar TXS 0506+056 as the first known astronomical source of high-energy neutrinos. Several questions, however, remain, pertaining to the precise origins of astrophysical neutrinos, their production mechanisms at the source and in Earth's atmosphere and in the context of physics beyond the Standard Model. This proceeding highlights some of our latest results, from new constraints on neutrino interactions and oscillations to the latest measurements of the astrophysical neutrino flux and searches for their origins to future prospects with IceCube-Gen2.