The surgical aspects of gastritis and its role in gastric pathology

Gilmour, J. R.

doi:10.1002/bjs.18004921510

Cited by 11 publications

(5 citation statements)

References 18 publications

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“…Studies, conducted in the first half of the 20th century, of surgical resection specimens suggested that chronic gastritis was more advanced in individuals with gastric cancer than in individuals with duodenal ulceration (6,7). Investigators also recognized that areas of gastric adenocarcinoma were frequently found in areas of chronic inflammation, as well as in settings of atrophic gastritis.…”

Section: Atrophic Gastritis and Gastric Cancermentioning

confidence: 99%

Inflammation, atrophy, and gastric cancer

Fox

Wang²

2007

J. Clin. Invest.

694

626

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The association between chronic inflammation and cancer is now well established. This association has recently received renewed interest with the recognition that microbial pathogens can be responsible for the chronic inflammation observed in many cancers, particularly those originating in the gastrointestinal system. A prime example is Helicobacter pylori, which infects 50% of the world's population and is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia, and gastric cancer. This Review provides an overview of recent progress in elucidating the bacterial properties responsible for colonization of the stomach, persistence in the stomach, and triggering of inflammation, as well as the host factors that have a role in determining whether gastritis progresses to gastric cancer. We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment.

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Section: Atrophic Gastritis and Gastric Cancermentioning

confidence: 99%

Inflammation, atrophy, and gastric cancer

Fox

Wang²

2007

J. Clin. Invest.

694

626

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“…At operation no ulcer was found, but a severe antral inflammation with multiple erosions. These cases do not occur with great frequency, and individual cases have been written up and are found scattered throughout the literature (for example, Papayannopoulos, Dedes, Kasralis, and Arealis, 1957;Gilmour, 1961). Faber noted that erosions did not occur with great frequency and this may be the result of most of the stomachs removed at operation being in a more or less quiescent stage.…”

Section: Classification Of the Inflammatory Changes Thementioning

confidence: 99%

The antrum in patients with duodenal and gastric ulcers.

Schrager¹,

Spink²,

Mitra³

1967

Gut

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EDITORIAL COMMENT In this histological study of surgical specimens it has been shown that duodenal ulcer is associated with mild inflammation and gastric ulcer with marked changes and degeneration with metaplasia.Very few detailed descriptions of the antrum are available in the literature, yet the importance of this organ has been stressed by many writers in the past (Konjetzny, 1928;Faber, 1935;Hebbel, 1943; Magnus, 1954;Dean and Mason, 1964; and others). An attempt has been made in this laboratory to study the gastric antrum in normal stomachs and in duodenal and gastric ulcer in greater detail. METHODSOne hundred and thirty specimens were examined. Seventy-five of these were surgical specimens from cases of duodenal ulcer and 40 from cases of gastric ulcer. Sixteen were from post-mortem specimens removed within a few hours of death, in which as far as could be ascertained, there was no question of gastrointestinal disease. The surgical specimens were opened immediately after operation by cutting along the greater curvature and they were pinned out with care on cork mats. They were formalin fixed immediately. The specimens with duodenal ulcer had a cuff of duodenum some 5 cm. in width. The amount of duodenum in gastric ulcer specimens was much reduced, but all the specimens showed an intact sphincter. The proximal portion of the specimen consisted of gastric mucosa.After fixation, the specimens were photographed. The size of the photograph was exactly the same as the size of the stomach. A tracing was made from the photograph onto thin paper. The whole of the specimen was cut into longitudinal strips 1-Ij cm. broad. Transverse cuts were then made through the strips at three places, the result being 30-40 shorter pieces measuring approximately 6 cm. in length. A plan of these cut strips was made on the tracing from the stomach. The strips were numbered and these numbers entered on the plan. The strips were then processed, blocked in wax, and sectioned on a sledge microtome. The boundary between the antrum and the body mucosa was studied and mapped out and the surface area of the antrum measured with a planimeter. This procedure enabled us to study thoroughly all of the gastric mucosa and get acquainted with the whole of its cellular topography.The stains used in this study were haematoxylin and eosin and Zimmerman's stain using the method described by Marks and Drysdale (1957); also 30 specimens were stained with Van Gieson stain. The Zimmerman stain was used to show up well the parietal, peptic, and mucous cells. The Van Gieson stain was used to show the increase in fibrous tissue in the mucosa and submucosa. RESULTS CLASSIFICATION OF THE INFLAMMATORY CHANGES Theinflammatory changes in the antral mucosa were classified as follows: 1 Changes showing inflammatory reaction and no destruction of pyloric glands, and according to severity, divided into grades Al and A2 (Figs. 1 and 2); 2 changes resulting in damage and destruction of the pyloric glands with increasing amounts of intestinalization. The final stage s...

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“…The stomach was opened in one of three positions: the antrum, fundus, or antrofundic junction, which is situated midway between the greater and lesser curvatures, in line with the right border of the oesophagus. The workers believe that in the development of gastric ulceration in the human subject, gastritis occurs first and, when the ability of the mucosa to react is finally overcome, gastric ulceration will occur (Gilmour, 1961; Spira, 1956;du Plessis, 1960du Plessis, , 1962du Plessis, , 1963du Plessis, , 1965. In this investigation the reaction of atrophic mucosa has been studied while these areas were in contact with the gastric juices.…”

Section: Department Of Surgery University Of the Witwatersrand And Tmentioning

confidence: 99%

Gastritis and gastric ulceration

Lawson

1966

Journal of British Surgery

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The surgical aspects of gastritis and its role in gastric pathology

Cited by 11 publications

References 18 publications

Inflammation, atrophy, and gastric cancer

Inflammation, atrophy, and gastric cancer

The antrum in patients with duodenal and gastric ulcers.

Gastritis and gastric ulceration

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