The surgical Treatment and Outcome of Pathological Fracture in Patients with Giant Cell Tumor of Bone

Abstract

Between 1992 and 2008, we treated 35 patients with giant cell tumor (GCT) of bone, seven of the 35 pre-sented with a pathological fracture. The fractures were located in the femur in five, and in the humerus and radius in one patient each. The surgical treatments were curettage in six cases and wide resection in the distal radius case. Two of the seven patients developed local recurrence, giving a local recurrence rate of 29%. The local recurrence rate in GCT patients without a pathological fracture was 21%. There was a tendency for there to be a higher recurrence rate associated with fractured GCT, but no statistically significant difference was observed between the two groups. Therefore, it was considered that a pathological fracture was not a risk factor for local recurrence in GCT

Wide resection versus curettage in giant cell tumor with pathological fracture? A systematic review and meta-analysis

“…The full texts of the remaining 43 papers were reviewed and 38 were excluded. We finally selected 05 articles for the meta-analysis [1][2][3][4][5] (Fig. 1), (Table 3).…”

“…[5][6][7][8][9][10][11][12] The patients with giant cell tumor develop pathological fracture in approximately 9-30% cases. [1][2][3][4][5][6][7][8][9][10][11] The presence of a pathological fracture is considered as a factor in decision making for treatment of giant cell tumor.…”

“…Inherent biases could exist, in terms of patient selection, heterogeneous treatment regimes and loss to follow-up. Newcastle-Ottawa scale was used and showed that the quality of 2 3 35 23 7 Jeys et al 3 -54 30 12 Blackley et al 4 6.7 59 12 17 McDonald et al 5 9.2 221 21 31 the evidence was good. The studies used different methods of reconstruction, different types of adjuvant treatment, different sites of involvement and the variable extent of involvement of the soft-tissues and adjacent joint.…”

“…The prevalence of pathological fractures ranges between 9% and 30% of patients with giant cell tumor (GCT) of extremities. [1][2][3][4][5][6][7][8][9] Pathological fracture leads to severe pain, immobilization of limb, decreased ambulation, affects activities of daily living and quality of life. Presence of a pathological fracture may lead traditionally to the local hematoma formation causing spread of tumor cells to adjacent tissue and joint contamination.…”

Mid-term results of giant cell tumours with pathologic fractures around the knee: a multicentre retrospective study

“…The results of patients with fractures in the GTOC was in complete accordance with the reported literatures. The widely accepted consensus of most authors is that pathologic fractures cause adjacent tissue contamination, causing the development of a surrounding tissue mass [ 3 , 4 , 21 , 28 – 32 ]. Our study is not only in accord with the reported literatures, but also indicates that soft tissue mass increases with the aggravation of complexity of fractures.…”