The survival impact of surgical therapy in squamous cell carcinoma of the hard palate

Alonso, José Eugenio Lozano; Han, Albert Y; Kuan, Edward C.; Strohl, Madeline P.; Clair, Jon Mallen–St.; John, Maie A. St.; Ryan, William R.; Heaton, Chase M.

doi:10.1002/lary.27080

Cited by 13 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, only two studies have examined the independent prognostic factors for survival in specific subsites of the oral cavity ( 15 , 16 ). In a study that described the incidence and determinants of survival of 1,489 patients with SCC of the hard palate between 1973 and 2014 using the SEER database, Alonso et al .…”

Section: Discussionmentioning

confidence: 99%

“…In a study that described the incidence and determinants of survival of 1,489 patients with SCC of the hard palate between 1973 and 2014 using the SEER database, Alonso et al . found that advanced age, nonoperative treatment, radiation therapy, tumor stage and grade were independently associated with worse overall survival ( 15 ). In the current study, in addition to tumor stage, male gender and low education level were also independently associated with poor survival in patients with SCC of the hard palate.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic factors associated with overall survival in patients with oral cavity squamous cell carcinoma

Oliveira¹,

Bergmann²,

Melo³

et al. 2020

Med Oral

View full text Add to dashboard Cite

Background Low socioeconomic status, increasing age, and poor lifestyle behaviors are associated with poor survival in patients with oral cavity squamous cell carcinoma (OCSCC). To determine the overall survival (OS) and the risk of OCSCC death by tumor subsite. Material and Methods A retrospective cohort study of OCSCC patients diagnosed from 2007 to 2009 and treated at a single cancer center in Rio de Janeiro, Brazil. Patient information was obtained from the Hospital Cancer Registry (HCR) database and complemented by individual search of physical and electronic medical records. Descriptive statistics of population characteristics were computed. OS was estimated using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards regression analyses were used to estimate the risk of death by tumor subsite. Results Seven hundred and three patients with OCSCC were identified. Most patients were men (77.4%) with low levels of education (67.5%), who drank (73.9%) and smoked (79.7%). The most prevalent tumor site was the tongue (45.4%), 73.4% of patients had advanced (clinical stage III or IV) OCSCC at diagnosis and 74.1% died during follow-up. For the entire cohort, the OS was 39.1% at two years and 27.9% at five years. The median survival time was 1.4 years (95%CI: 1.2‒1.5). Non-operative treatment (HR: 3.11; 95%CI: 2.26‒4.29; p <0.001), advanced stage (HR 2.14; 95%CI 1.68-2.74; p <0.001), and age >60 years at diagnosis (HR: 1.37; 95%CI: 1.15‒1.64; p <0.001) were independently associated with the risk of death. However, these factors varied by tumour subsite. Conclusions Analysis of specific subsites of the oral cavity revealed substantial differences in prognostic factors associated with poor survival in OCSCC. Key words: Squamous cell carcinoma, oral cavity cancer, survival, prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic factors associated with overall survival in patients with oral cavity squamous cell carcinoma

Oliveira¹,

Bergmann²,

Melo³

et al. 2020

Med Oral

View full text Add to dashboard Cite

show abstract

“…Surgery of hard palate cancer frequently does not include removal of the underlying bone [129]. However, management guidelines specifically pertaining to hard palate cancer are based on expert opinion owing to scant evidence [130]. Enucleation is avoided for hard palate cancer because it is associated with a high risk of recurrence whether enucleation is safe for hard palate cancer remains unknown [131].…”

Section: Guidelines For Surgical Treatment Of Oral Cancermentioning

confidence: 99%

Guidelines for the Surgical Management of Oral Cancer: Korean Society of Thyroid-Head and Neck Surgery

Joo

Cho

Koo

et al. 2019

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

Korean Society of Thyroid-Head and Neck Surgery appointed a Task Force to provide guidance on the implementation of a surgical treatment of oral cancer. MEDLINE databases were searched for articles on subjects related to “surgical management of oral cancer” published in English. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. The quality of evidence was rated with use RoBANS (Risk of Bias Assessment Tool for Nonrandomized Studies) and AMSTAR (A Measurement Tool to Assess the Methodological Quality of Systematic Reviews). Evidence-based recommendations for practice were ranked according to the American College of Physicians grading system. Additional directives are provided as expert opinions and Delphi questionnaire when insufficient evidence existed. The Committee developed 68 evidence-based recommendations in 34 categories intended to assist clinicians and patients and counselors, and health policy-makers. Proper surgical treatment selection for oral cancer, which is directed by patient- and subsite-specific factors, remains the greatest predictor of successful treatment outcomes. These guidelines are intended for use in conjunction with the individual patient’s treatment goals.

show abstract

“…Patients with early-stage squamous cell carcinoma (ESCC; TNM I and II) survive longer than those with advanced-stage squamous cell carcinoma (ASCC; TNM III and IV), with survival rates of 64.2 and 30.1% for early and late stages, respectively (4). Despite improvements in treatment modalities, the 5-year overall survival rate has improved only marginally, with 33% of cases surviving between 1973 and 2014, compared with 41% between 2006-2011 (5,6). Delayed diagnosis and the lack of accurate and timely treatment, derived from the bias of the standards of clinical decision-making based on the clinical experience and subjective judgment of doctors, are considered to be the major reasons for the poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma

2021

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC), characterized by a high recurrence rate, a poor prognosis and high morbidity, is the most prevalent malignancy of the oral cavity. The aberrant expression of long non-coding RNAs (lncRNAs) may lead to the development of various diseases, including cancer. Delayed diagnosis is the main reason for the poor prognosis. Therefore, the present study aimed to investigate the differential expression profiles of plasma lncRNAs in OSCC in order to screen target lncRNAs as biomarkers for the early diagnosis and staging of OSCC. The expression profiles of lncRNAs and mRNAs in OSCC were analyzed by microarray analysis. A total of 14 candidate lncRNAs were selected and analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) using the array homologous samples. Subsequently, 4 target lncRNAs were measured by RT-qPCR in a large cohort, including 28 cases with TNM I/II [early-stage squamous cell carcinoma (ESCC) group], 36 cases with TNM III/IV [advanced-stage squamous cell carcinoma (ASCC) group], 16 cases with dysplasia [oral premalignant lesion (OPL) group] and 16 healthy controls (H group). Receiver operating characteristic (ROC) curves and logistic regression analysis were used to evaluate the diagnostic effects of the combined lncRNAs. In total, 6,606 differentially expressed lncRNAs and 4,196 mRNAs were identified in OSCC. The expression trend of the 14 candidate lncRNAs was consistent with the microarray data. The expression level of ENST00000412740, NR_131012, ENST00000588803 and NR_038323 exhibited significant differences in the H, OPL, ESCC and ASCC groups (P<0.05). ROC curve and logistic regression analyses revealed that the diagnostic efficacy of the combined lncRNAs was more prominent than that of a single lncRNA, particularly in the ESCC and ASCC groups. In conclusion, the present study identified the differential expression profiles of plasma lncRNAs in OSCC and demonstrated that ENST00000412740, NR_131012, ENST00000588803 and NR_038323 may be promising biomarkers for the early diagnosis and staging of OSCC. These findings may provide novel targets for the early diagnosis and staging of OSCC, which may provide an objective basis for clinical decision-making.

show abstract

The survival impact of surgical therapy in squamous cell carcinoma of the hard palate

Abstract: 4. Laryngoscope, 128:2050-2055, 2018.

Cited by 13 publications

References 18 publications

Prognostic factors associated with overall survival in patients with oral cavity squamous cell carcinoma

Prognostic factors associated with overall survival in patients with oral cavity squamous cell carcinoma

Guidelines for the Surgical Management of Oral Cancer: Korean Society of Thyroid-Head and Neck Surgery

Screening and validation of plasma long non‑coding RNAs as biomarkers for the early diagnosis and staging of oral squamous cell carcinoma

Contact Info

Product

Resources

About