The susceptibility of the goat to Fasciola hepatica infections

Reddington, John J.; Leid, R. Wes; Wescott, Richard B.

doi:10.1016/0304-4017(86)90042-7

Cited by 33 publications

(14 citation statements)

References 17 publications

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“…These authors found that only 2% of wild sheep (Ovis ammon orientalis) were parasitised by F. hepatica, while prevalence was 0% for goitered gazelle (Gazella subgutturosa) surveyed in Iran. On the contrary, domestic hosts, such as goats and sheep, show a higher susceptibility to liver fluke (Reddington et al 1986;Khallaayoune et al 1991). Eslami et al (1981) suggested that the absence of the intermediate host in the habitat used by these wild ungulates was the reason explaining such low prevalence values.…”

Section: Discussionmentioning

confidence: 94%

Epidemiology of fasciolosis affecting Iberian ibex (Capra pyrenaica) in southern Spain

et al. 2007

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Between 1995 and 2006, we surveyed the presence of Fasciola hepatica in Iberian ibex (Capra pyrenaica) from Andalucía (southern Spain) by both necropsy (n = 2,096) and coprological approaches (n = 380). Most of the samples came from the Sierra Nevada mountain range (n = 1,884 and 267, respectively), and all positive cases involved animals from this location. The prevalence reached 0.53% by necropsy and 1.87% by faecal examination. Taking into account both diagnostic methodologies and the total number of animals affected (n = 14), we obtained a yearly prevalence of 0.7 +/- 0.3%. The infection with F. hepatica was found not to be related to host sex, climatology or to co-infection with Sarcoptes scabiei (the most important parasite affecting Iberian ibex, with a prevalence of 49.27 +/- 7.90% in the examined animals). The prevalence of fasciolosis decreased significantly during the period under study and this would be explained by an increase of ibex resistance to this fluke as a result of a reduction of the parasite abundance in the area and/or a reduction of the host infection rate. There was no statistical difference between the two diagnostic methods for the examination of fasciolosis during the period in which both methods were used. Therefore, examination of faecal samples as a non-invasive procedure may provide a useful approach for monitoring fasciolosis in wild ungulate populations. The results of the present study provided foundation for the effective control of F. hepatica infection in Iberian ibex.

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Section: Discussionmentioning

confidence: 94%

Epidemiology of fasciolosis affecting Iberian ibex (Capra pyrenaica) in southern Spain

et al. 2007

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“…Protective immunity has been elicited in F. gigantica infections (Haroun et al 1989), but no resistance to F. hepatica primary or secondary infections has been observed (Reddington et al 1986). However, the nature of the immune mechanisms underlying these responses has not been clearly established.…”

Section: Introductionmentioning

confidence: 99%

Humoral and cellular immune responses to experimental Fasciola hepatica infections in goats

Martı́nez-Moreno

Martínez-Moreno

Acosta

et al. 1997

Parasitology Research

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Humoral and cellular immune responses to Fasciola hepatica excretory-secretory products (ESPs) in primary and secondary experimental infections in goats were studied. Primary infection induced the development of chronic subclinical fascioliasis that did not affect the establishment of flukes coming from the secondary infection, as the same percentages of recovered flukes were found in both groups. The specific IgG response to F. hepatica ESPs was similar in primary and secondary infections; challenge flukes did not induce any modification in the IgG response. The specific lymphocyte response to F. hepatica ESPs was absent in most of the infected goats, both primarily and secondarily infected. A modulation of the nonspecific cellular responses to mitogens was also observed. All infected goats showed a reduced proliferative response to concanavalin A and phytohemagglutinin. According to our results, humoral and cellular responses to F. hepatica ESPs in goats have no protective effect on the establishment of flukes and the development of disease in either primary or secondary infections.

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“…In cattle, subacute or acute outbreaks occasionally occur, whereas in sheep, acute or subacute diseases are more frequent (Radostits et al 2007). Goats can be considered a very receptive host for F. hepatica based on the recovery of mature flukes from primary and secondary infections, (Reddington et al 1986) and although the infection usually evolves as a chronic disease, subacute and acute fasciolosis with high rates of mortality are not rare (Leathers et al 1982). Although there are several papers about clinical signs, epidemiology and macroscopic and microscopic features of F. hepatica in goats, to the our knowledge, there is no document describing acute caprine fasciolosis caused by F. gigantica.…”

Section: Introductionmentioning

confidence: 99%

Acute caprine fasciolosis: a case with unusual migration to lung

et al. 2013

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Fasciolosis is an important parasitic disease of domestic ruminants and occurs worldwide as a result of infection with liver fluke species. This report describes the macroscopic and microscopic characteristics of acute fasciolosis in a goat with unusual migration to lung. A 10-month-old goat was presented with history of weakness and acute recumbency from 12 h ago. The clinicians didn't report clinical evidence of systemic disease. Hematological analysis showed no significant changes in blood parameters except a mild reduction in lymphocyte population and about 6 % eosinophilia and also normocytic normochromic anemia. A noticeable increase in the level of serum ALP, AST and also GLDH were observed. Moreover, total protein and albumin showed a slight decrease in value comparing to reference intervals. In macroscopic examination numerous short vermiform cords were noted on the liver surface and the surface had an uneven appearance. A large number of immature, wandering flukes were seen on the cut surface. Histopathologically, a wide range of hepatic lesions was found. The most important lesions were moderate to severe perihepatitis and haemorrhagic tracts on the hepatic surface. These lesions corresponded to migratory tunnels filled with blood, fibrin and cellular debris. However histopathological findings of lung revealed chronic suppurative bronchopneumonia, but this lesion is not only associated with larval migration.

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The susceptibility of the goat to Fasciola hepatica infections

Cited by 33 publications

References 17 publications

Epidemiology of fasciolosis affecting Iberian ibex (Capra pyrenaica) in southern Spain

Epidemiology of fasciolosis affecting Iberian ibex (Capra pyrenaica) in southern Spain

Humoral and cellular immune responses to experimental Fasciola hepatica infections in goats

Acute caprine fasciolosis: a case with unusual migration to lung

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