The Susceptibility Patterns of Candida Species Isolated From Urine Samples to Posaconazole and Caspofungin

Mahmoudabadi, Ali Zarei; Rezaei‐Matehkolaei, Ali; Ghanavati, Fataemeh

doi:10.5812/jjm.24298

Cited by 20 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As already mentioned in most studies, among Candida species, C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. krusei were the most common causes of candidiasis in Iran. Several studies showed that Candida onychomycosis was the predominant yeast infection (2,5,19,21), consistent with the current study results (41.8%). In the current study, the most prevalent species isolated from clinical samples was C. albicans, followed by C. parapsilosis, C. tropicalis, and C. guilliermondii.…”

Section: Discussionsupporting

confidence: 93%

“…In epidemiological studies, most of the yeast isolates belong to Candida species, especially C. albicans (1,4,5,17,18). Previous studies in different regions of Iran show that Candida species were isolated from various clinical samples rather than other yeasts (2,5,(18)(19)(20)(21)(22)(23). As already mentioned in most studies, among Candida species, C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. krusei were the most common causes of candidiasis in Iran.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Identification of Clinically Common and Uncommon Yeast Species

Shokohi

Moradi

Badram

et al. 2018

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: The incidence of fungal infections caused by the yeasts and yeast-like species increased dramatically in immunocompromised patients, during the past several decades. However, a few of yeast and yeast-like species may colonize in skin and mucous membranes of healthy individuals. Objectives: The current study aimed at accurately identifying yeast and yeast-like species from clinical samples by molecular methods. Methods: A total of 1200 clinical samples were collected from patients with suspected fungal infection and 110 (9.16 %) yeast and yeast-like strains isolated and identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), PCR amplification of hwp1 gene, and sequencing. Results: In total, Candida albicans (n = 46) was the most frequently isolated species followed by C. parapsilosis complex (n = 17), C. tropicalis (n = 13), C. guilliermondii (n = 12), C. glabrata (n = 4), C. krusei and C. famata each (n = 3), C. kefyr, C. haemulonii and Cutaneotrichosporon jirovecii each (n = 2), and C. stellatoidea, C. intermedia, C. sorbosivorans, C. africana, Pichia kudriavzevii, and Trichosporon asahii each (n = 1). Interestingly, C. haemulonii, a multidrug resistant fungus was isolated from cutaneous and sputum samples for the first time in Iran. Conclusions: Nowadays, with growing population at risk for fungal infections and the emergence of some less virulent or nonpathogenic and uncommon yeasts not readily distinguishable with phenotypic assays, the accurate identification using molecular methods are warranted.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Molecular Identification of Clinically Common and Uncommon Yeast Species

Shokohi

Moradi

Badram

et al. 2018

Jundishapur J Microbiol

View full text Add to dashboard Cite

show abstract

“…Also, a POS MIC90 value of 0.06 μg/ml was reported in C. albicans and 2 μg/ml for C. glabrata isolates in Castanheira et al [ 13 ]. In Mahmoudabadi et al 94% of the isolates were inhibited by POS at < 2 μg/mL after 24 h, whereas 6% of isolates had MICs of > 4 μg/mL [ 20 ]. According to the present study, the ECV and MIC90 values of POS in C. krusei were 0.5 μg/ml, and POS is the best antifungal agent for the treatment of infections due to this species.…”

Section: Discussionmentioning

confidence: 99%

“…Espinel-Ingrof et al reported that CAS MICs value evaluation for some Candida species (such as C. glabrata and C. krusei according to CLSI breakpoints is not suitable and could lead to reporting an excessive number of wild-type or non-wild type isolates [ 23 ]. In Mahmoudabadi et al the MIC of CAS in 90% of the total INFECT Candida isolates was lower than 2 μg/mL [ 20 ]. In Abad et al MIC values for CAS in C. albicans , C. parapsilosis complex, C. tropicalis , C. glabrata complex, C. guilliermondii and C. krusei were reported as 0.008 μg/ml, 2 μg/ml, 0.12 μg/ml, 0.12 μg/ml, 2 μg/ml, and 0.5 μg/ml, respectively [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates

et al. 2017

View full text Add to dashboard Cite

BackgroundAntifungal susceptibility testing is a subject of interest in the field of medical mycology. The aim of the present study were the distributions and antifungal susceptibility patterns of various Candida species isolated from colonized and infected immunocompromised patients admitted to ten university hospitals in Iran.MethodsIn totally, 846 Candida species were isolated from more than 4000 clinical samples and identified by the API 20 C AUX system. Antifungal susceptibility testing was performed by broth microdilution method according to CLSI.ResultsThe most frequent Candida species isolated from all patients was Candida albicans (510/846). The epidemiological cutoff value and percentage of wild-type species for amphotericin B and fluconazole in Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei were 0.5 μg/ml (95%) and 4 μg/ml (96%); 1 μg/ml (95%) and 8 μg/ml (95%); 0.5 μg/ml (99%) and 19 μg/ml (98%); and 4 μg/ml (95%) and 64 μg/ml (95%), respectively. The MIC90 and epidemiological cutoff values to posaconazole in Candida krusei were 0.5 μg/ml. There were significant differences between infecting and colonizing isolates of Candida tropicalis in MIC 90 values of amphotericin B, and isolates of Candida glabrata in values of amphotericin B, caspofungin, and voriconazole (P < 0.05).ConclusionsOur findings suggest that the susceptibility patterns of Candida species (colonizing and infecting isolates) in immunocompromised patients are not the same and acquired resistance was seen in some species.

show abstract

“…In another study, C. tropicalis 3.9%, C. parapsilosis 4.9%, C. dubliniensis 1.5%, and no C. kefyr were reported (18). Another study revealed the rates of non-albicans Candida were C. krusei (14%), C. tropicalis (16%), and C. glabrata (24%) (19). The existing differences in the distributions may be due to differences in the places where the studies were conducted.…”

Section: Discussionmentioning

confidence: 97%

The Relative Frequency and Susceptibility Patterns of Candida Species Isolated from Blood and Urine of Children with Malignancy

Shamsizadeh

Nikfar

Mombini

et al. 2018

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Systemic candidiasis has been on the rise in recent years due to the increasing number of patients with malignancies and use of immunosuppressants. The present study seeks to identify the distribution of Candida species isolated from malignant patients and determine in vitro antifungal susceptibility patterns of the isolates to promote their effective management. Methods: Blood and urine samples from 385 patients with malignancies were cultured. Identification and susceptibility patterns of the Candida isolates from clinical samples to antifungal drugs were done using API 20C AUX system and microdilution methods. Results: From 90/385 patients (23.4%), 102 Candida spp. were isolated. The most prevalent species was Candida albicans with sensitivity rates of 91%, 96%, 100%, 96%, and 60% to fluconazole, amphotericin B, caspofungin, voriconazole, and itraconazole, respectively. Epidemiological cutoff values for amphotericin B and voriconazole were 0.064 and 0.032, respectively. All the isolated species were of wild-type for all antifungal agents except 4% of Candida albicans, which were non-wild type to amphotericin B and voriconazole and 6% to itraconazole. No relationship was seen between the rate of isolated species and sex, age, and the type of malignancy; but the relationship between the use of antibacterial agents and Candida isolation was significant (P < 0.05). Conclusions: Mutations in drug sensitivity were found in some species (non-wild type). As there was a relationship between the use of antibacterial agents and the isolation of Candida species from immunocompromised patients, accurate diagnosis of Candida species isolated and their antifungal susceptibility patterns are needed for the management of such patients.

show abstract

The Susceptibility Patterns of Candida Species Isolated From Urine Samples to Posaconazole and Caspofungin

Cited by 20 publications

References 20 publications

Molecular Identification of Clinically Common and Uncommon Yeast Species

Molecular Identification of Clinically Common and Uncommon Yeast Species

Antifungal susceptibility testing of Candida species isolated from the immunocompromised patients admitted to ten university hospitals in Iran: comparison of colonizing and infecting isolates

The Relative Frequency and Susceptibility Patterns of Candida Species Isolated from Blood and Urine of Children with Malignancy

Contact Info

Product

Resources

About