The Swelling Behaviors of poly(2-acrylamido-2-methyl-1-propane sulfonic acid co-1-vinyl-2-pyrrolidone) Hydrogels

Çavuş, Selva; Çakal, Elçin

doi:10.12693/aphyspola.134.129

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…This decreased swelling percentage was ascribed to the reduced porous network structure and diffusion due to increased crosslinked density. Çavuş and Çakal also reported same swelling trend by incremental rise of crosslinker 32 …”

Section: Resultsmentioning

confidence: 55%

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Rehman

Sarfraz

Mahmood

et al. 2021

Polymers for Advanced Techs

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This project was designed to develop pH responsive smart chitosan/agarose‐g‐poly (methacrylate) hydrogels using free radical polymerization for targeted delivery of Capecitabine (a prodrug of 5‐fluorouracil) for the treatment of colorectal cancer. Developed hydrogels were evaluated for drug loading efficiency, thermal stability, compatibility of components, morphology, swelling behavior, release kinetics and acute oral toxicity studies in rabbits. Moreover, pharmacokinetic parameters were also measured in healthy rabbits. Structural entanglement was confirmed via FTIR providing evidence of hydrogel formation. Loading of Capecitabine was in range from 60.35% to 62.57%. Hydrogels showed pH‐responsive behavior by providing maximum swelling of 93.84% at pH 7.4 identical to colon. Release of Capecitabine from hydrogels was in controlled pattern over a period of 36 h. Toxicity studies revealed no signs of ocular, dermal and oral toxicity providing safety evidence of hydrogels. In addition, pharmacokinetic evaluations of Capecitabine loaded hydrogels showed significant increase in plasma half‐life of 17 h and AUC of 57.65 μg.h/ml in comparison to pure Capecitabine solution. Therefore, these results strongly suggest that newly formed hydrogels are biocompatible, capable of providing sustained release at specific pH and can be employed as a cargo for colorectal delivery.

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Section: Resultsmentioning

confidence: 55%

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Rehman

Sarfraz

Mahmood

et al. 2021

Polymers for Advanced Techs

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Development of pH‐responsive Hydrogel from Copolymers of Artemisia vulgaris Seed Mucilage, Mucin, and poly(methacrylate) for Controlled Delivery of Acyclovir Sodium

Taslim,

Ashraf,

Farooq

et al. 2024

Macromol. Rapid Commun.

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To cope with the constraints of conventional drug delivery systems, site‐specific drug delivery systems are the major focus of researchers. The present research developed water‐swellable, pH‐responsive methacrylic acid‐based hydrogel scaffolds of Artemisia vulgaris seed mucilage with mucin and loaded with acyclovir sodium as a model drug. The developed hydrogel discs are evaluated for diverse parameters. Drug loading efficiency in all formulations ranges from 63% to 75%. The hydrogels exhibited pH‐dependent swelling, displaying optimum swelling in a phosphate buffer (pH 7.4), and insignificant swelling in an acidic buffer (pH 1.2), in addition, they responded well to electrolyte concentrations. The sol‐gel fraction is estimated ranging from 60 to 95%. Dissolution studies unveiled sustained drug release for 24 h in a phosphate buffer of pH 7.4, exhibiting zero‐order release kinetics. Moreover, FTIR spectra confirmed the drug‐excipient compatibility. SEM photomicrographs revealed a rough and porous surface of hydrogel discs with several pores and channels. The PXRD diffractograms exposed the amorphous nature of the polymeric blends. The findings of acute toxicity studies proved the developed hydrogel network is biocompatible. Therefore, these outcomes connote the newly created network as a smart delivery system, able to dispatch acyclovir sodium into the intestinal segment for a prolonged period.

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Analysis of a constant-volume diafiltration system with the ability to remove lithium cations when using poly(2-acrylamido-2-methyl-1-propanesulfonic acid) in water

Tapiero,

Sánchez

2024

Journal of Water Process Engineering

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The Swelling Behaviors of poly(2-acrylamido-2-methyl-1-propane sulfonic acid co-1-vinyl-2-pyrrolidone) Hydrogels

Cited by 5 publications

References 12 publications

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Chitosan/Agarose‐g‐poly (methacrylate) pH responsive polymeric blend: A dais for controlled delivery of Capecitabine

Development of pH‐responsive Hydrogel from Copolymers of Artemisia vulgaris Seed Mucilage, Mucin, and poly(methacrylate) for Controlled Delivery of Acyclovir Sodium

Analysis of a constant-volume diafiltration system with the ability to remove lithium cations when using poly(2-acrylamido-2-methyl-1-propanesulfonic acid) in water

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