1952
DOI: 10.1161/01.cir.5.5.693
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The Syndrome of Short P-R Interval Normal QRS Complex and Paroxysmal Rapid Heart Action

Abstract: A short A-V conduction time, whether present with normal or with abnormal QRS complex, is associated with an increased incidence of paroxysmal rapid heart action. There are a considerable number of patients who have a short P-R interval, normal QRS complex and bouts of tachycardia. They are usually females, in middle life, devoid of organic heart disease and exhibit a snapping apical first heart sound. They do not demonstrate any of the features of anomalous A-V conduction. Evidence is presented suggesting the… Show more

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Cited by 246 publications
(59 citation statements)
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“…These features are consistent with the type of ventricular pre-excitation first described by Lown et al (1952), in which the tachycardia, usually nodal re-entrant tachycardias, are the result of either circus movement involving the atrioventricular node and an atrioventricular nodal bypass, i.e. James bundle (James, 1961;Ward et al, 1978), or an intra-atrioventricular nodal abnormality (Caracta et al, 1973).…”
Section: Discussionsupporting
confidence: 84%
“…These features are consistent with the type of ventricular pre-excitation first described by Lown et al (1952), in which the tachycardia, usually nodal re-entrant tachycardias, are the result of either circus movement involving the atrioventricular node and an atrioventricular nodal bypass, i.e. James bundle (James, 1961;Ward et al, 1978), or an intra-atrioventricular nodal abnormality (Caracta et al, 1973).…”
Section: Discussionsupporting
confidence: 84%
“…16 17 The right choice of treatment in patients with WPW syndrome and recurrent tachyarrhythmias is important and the following facts must be borne in mind: (1) Most attacks occur in infants who are likely to develop cardiac failure, and immediate termination of the arrhythmia is imperative. (2) The use of drugs in order to convert the arrhythmia in these young infants must be safe with a wide margin between the therapeutic and toxic dosages.…”
Section: Discussionmentioning
confidence: 99%
“…In EAVNC, the P-R interval is shortened and A-V conduction time is decreased. [2][3][4][5][6] Several mechanisms have been proposed to explain short P-R intervals in EAVNC, including a partial bypass of the A-V node, an underdeveloped or anatomically small A-V node, and an anatomically normal A-V node that has rapid conduction properties either intrinsically or as a result of alterations in autonomic tone, [6][7][8][9][10][11][12] but the subject has not been resolved. A transgenic (TG) mouse with cardiacspecific overexpression of SCN5A (which encodes the cardiac sodium channel Na V 1.5) was recently developed and studied by Zhang et al 13 In this mouse model, prominent functional manifestations of overexpression of SCN5A included shortening of the P wave and the P-R interval on the surface electrocardiogram (ECG).…”
Section: Introductionmentioning
confidence: 99%