The syndrome of transient epileptic amnesia

Butler, Chris; Graham, Kim S.; Hodges, John R.; Kapur, Narinder; Wardlaw, Joanna M.; Zeman, Adam

doi:10.1002/ana.21111

Cited by 253 publications

(366 citation statements)

References 37 publications

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“…The typical interictal cognitive profile of TEA that comprises autobiographical memory loss and accelerated rate of forgetting (ALF) 4,5 was found in a subset of our patients with TEA. This profile, although suggestive of the syndrome, is thus inconstant, and has also been described in other forms of TLE.…”

Section: In Response: Transient Epileptic Amnesiamentioning

confidence: 69%

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Epileptic syndromes may be misleading

Lüders

2014

Epilepsia

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Section: In Response: Transient Epileptic Amnesiamentioning

confidence: 69%

“…The mean age of event onset is in the late 50s or early 60s 3,4 2. Secondary generalized seizures are rare (<10%) 5 3. The duration of the episodes of amnesia is unusually long (usually >5 to 10 minutes in duration) 5 …”

mentioning

confidence: 99%

Epileptic syndromes may be misleading

Lüders

2014

Epilepsia

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“…Similarly, forgetting over a four-day delay has been found to be greater in those with epileptiform discharges during that time period than those with normal EEG [105]. One question that arises from this work is whether activity during sleep accounts for ALF, particularly since impaired memory in people with epilepsy has been identified following 24-hour delays [106], sleep complaints are common in people with simple and complex partial seizures [107], people with Transient Epileptic Amnesia (who commonly display ALF) often experience amnestic episodes upon awakening prior to treatment [108], and people with TLE and bilateral mesial temporal sclerosis show reduced strengthening of memories during sleep [109].…”

Section: Possible Mechanisms For Alfmentioning

confidence: 89%

“…Transient Epileptic Amnesia (TEA) is a recently described subtype of TLE presenting with predominantly amnestic symptoms, usually in middle aged or elderly individuals [108,133,134]. The seizures of TEA often occur on waking and typically involve periods of anterograde and/or retrograde amnesia lasting for around 30 min.…”

Section: Epilepsy and Autobiographical Memorymentioning

confidence: 99%

Third International Congress on Epilepsy, Brain, and Mind: Part 2

Rektor¹,

Schachter²,

Arya³

et al. 2015

Epilepsy & Behavior

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*Corresponding author at: 165 Cambridge Street, Suite 702, Boston, MA 02114, USA. Tel.: +1 617 643 3835. sschacht@bidmc.harvard.edu (S.C. Schachter). Conflict of interestNone of the authors have any conflicts of interest to disclose. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptEpilepsyis both a disease of the brain and the mind. Here, we present the first of two papers with extended summaries of selected presentations of the Third International Congress on Epilepsy, Brain and Mind (April 3-5, 2014; Brno, Czech Republic). Epilepsy in history and the arts and its relationships with religion were discussed, as were overviews of epilepsy and relevant aspects of social cognition, handedness, accelerated forgetting and autobiographical amnesia, and large-scale brain networks.

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“…27 It has been suggested that a degenerative process exists in parallel with the epileptic disorder. 28 …”

Section: Epileptic Disordersmentioning

confidence: 99%

How Reversible are ‘˜Reversible Dementias’?

Ioannidis¹,

Karacostas²

2011

European Neurological Review

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Reversible dementias comprise different groups of disorders of variable aetiologies, such as structural brain lesions or metabolic, infectious, toxic, autoimmune, paraneoplastic and psychiatric disorders. When patients present with cognitive symptoms, especially in the younger age groups, the first thought of the attending neurologist should be to try to identify an underlying treatable cause. The incidence of degenerative dementia rises with older age and its symptoms progressively become more evident and typical; in such cases, a differential diagnosis is limited and the chance of uncovering a treatable disorder is minimal. However, although uncommon, treatable dementias or dementia-like symptoms do exist. Future studies with better design and methodology, as well as longer observation periods and larger patient populations, are needed to clarify the controversial issues concerning the epidemiology and accurate diagnosis of, and treatment possibilities for, reversible dementias. KeywordsReversible dementia, classification, differential diagnosis, treatment, review 1 It is estimated that the number of people with dementia will increase dramatically over the next few decades, 2 presenting a tremendous burden for patients, spouses and other family carers, and society. Consideration of the differential diagnosis of dementia is a complex process, and accurate diagnosis is challenging. Primary degenerative dementias result from irreversible aetiologies, such as beta-amyloid deposition, inclusion of Lewy bodies, taupathies or other dysfunctional proteins, whereas reversible dementias are secondary to other treatable conditions. When patients present with cognitive symptoms, especially in the younger age groups, the first thought of the attending neurologist should be to try to to identify an underlying treatable cause. Reversible dementias comprise different groups of variable aetiologies, such as structural brain lesions or metabolic, infectious, toxic, autoimmune, paraneoplastic and psychiatric disorders. 3 The aim of this article is first to define these treatable conditions and second to explore how reversible they really are according to data from the literature. 4,5 Traditional and New Approach to ReversibilityBetween the 1980s and early 1990s, most studies estimated the prevalence of reversible dementias to be almost 20 %, introducing aetiologies such as normal pressure hydrocephalus (NPH), structural brain abnormalities, depression, hypothyroidism and vitamin B12 deficiency. 6,7 However, many of these studies were lacking strict criteria, adequate follow-up and solid methodology. 8In recent years, neurologists have taken a new approach to reversibility.It seems that good history evaluation, clinical examination accompanied by certain psychometric tests and appropriate laboratory work-up should be considered for every patient with cognitive symptoms. 9The incidence of degenerative dementia rises with older age and its symptoms progressively become more evident and typical; in such cases, the differenti...

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The syndrome of transient epileptic amnesia

Abstract: We propose that transient epileptic amnesia is a distinctive epilepsy syndrome, typically misdiagnosed at presentation and associated with accelerated long-term forgetting and autobiographical amnesia. The syndrome is of clinical and theoretic importance.

Cited by 253 publications

References 37 publications

Epileptic syndromes may be misleading

Epileptic syndromes may be misleading

Third International Congress on Epilepsy, Brain, and Mind: Part 2

How Reversible are ‘˜Reversible Dementias’?

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