The synergetic enzyme theory of muscular contraction: II Relation between Hill's equations and functions of two-headed myosin

Shimizu, Hiroshi; Yamada, Tomonori; Nishiyama, Kenichi; Yano, Masahiro

doi:10.1016/0022-5193(76)90091-6

Cited by 7 publications

(1 citation statement)

References 28 publications

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“…Some studies [28–30] have argued that muscle internal inertia forces can be neglected. All these authors based their argument on assuming that the force within one sarcomere accelerates just one other sarcomere, that is, a very low mass.…”

Section: Introductionmentioning

confidence: 99%

Spreading out Muscle Mass within a Hill-Type Model: A Computer Simulation Study

Günther

Röhrle

Haeufle

et al. 2012

Computational and Mathematical Methods in Medicine

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It is state of the art that muscle contraction dynamics is adequately described by a hyperbolic relation between muscle force and contraction velocity (Hill relation), thereby neglecting muscle internal mass inertia (first-order dynamics). Accordingly, the vast majority of modelling approaches also neglect muscle internal inertia. Assuming that such first-order contraction dynamics yet interacts with muscle internal mass distribution, this study investigates two questions: (i) what is the time scale on which the muscle responds to a force step? (ii) How does this response scale with muscle design parameters? Thereto, we simulated accelerated contractions of alternating sequences of Hill-type contractile elements and point masses. We found that in a typical small muscle the force levels off after about 0.2 ms, contraction velocity after about 0.5 ms. In an upscaled version representing bigger mammals' muscles, the force levels off after about 20 ms, and the theoretically expected maximum contraction velocity is not reached. We conclude (i) that it may be indispensable to introduce second-order contributions into muscle models to understand high-frequency muscle responses, particularly in bigger muscles. Additionally, (ii) constructing more elaborate measuring devices seems to be worthwhile to distinguish viscoelastic and inertia properties in rapid contractile responses of muscles.

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Section: Introductionmentioning

confidence: 99%