The synergistic antifungal activity of resveratrol with azoles against Candida albicans

Abstract

Candida albicans is one of the most common clinical pathogenic microorganisms and it is becoming a serious health threat, particularly to immunocompromised populations. Drug resistance of Candida species has also frequently emerged, and combination therapy for fungal infections has attracted considerable attention. In this study, we established the Qinling Mountains myxobacterial secondary metabolites library and a synergic assay in combination with ketoconazole against C. albicans was introduced for metabolites screening. Two active compounds with synergic anticandidal activities were obtained, which were identified as trans‐resveratrol and cis‐resveratrol. According to our study, resveratrol can reduce the dosage to 1/64 of ketoconazole as well as itraconazole. Furthermore, synergistic anticandidal activity of resveratrol combined with azoles was verified against a panel of clinical C. albicans isolates, and the combination strategy enhanced the azoles susceptibility of three fluconazole‐resistant isolates. These findings suggest that resveratrol enhances the efficacy of azoles and provides a promising application in therapy of C. albicans infection.

Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier

“…Intriguingly, Houillé et al ( 53 ) found that resveratrol derivates has inhibiting effect on Candida albicans and non-albicans Candida (NAC) species in structure- and/or dose-dependent manner. Afterward, studies have revealed that resveratrol could induce Candida albicans apoptosis and have synergistic effect on azoles (an antifungal medicine) against Candida albicans ( 54 , 55 ). These findings suggest that it might be structure- and dose-dependent on the antimicrobial effect of resveratrol and its derivates.…”

The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mice

“…where A, B and C represent the ODs of the positive control, drug and negative control, respectively. The MIC 50 was determined as the concentration of tested compounds that inhibits fungal growth by 50% relative to the corresponding drug-free control (Wang et al 2021). The MIC 50 was calculated using the GraphPad Prism 7.0 software.…”

Antimicrobial Activity of Polyphenols and Natural Polyphenolic Extracts on Clinical Isolates

“…RSV could also significantly enhance the antifungal susceptibility of two of the three resistant fluconazole C. albicans strains tested. Itraconazole and ketoconazole in combination with RVS were then used against the resistant strain, obtaining antifungal effects; this indicates that when RSV alone is not effective, a combination with other azole drugs is an alternative strategy [ 41 ].…”