The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation

Ke, Jia; Li, Meng-Ting; Huo, Yajing; Cheng, Yan-Qiong; Guo, Shu-Fen; Wu, Yang; Zhang, Lei; Ma, Jianpeng; Liu, Aijun; Yan, Han

doi:10.2147/dddt.s318515

Cited by 27 publications

(27 citation statements)

References 76 publications

(93 reference statements)

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“…As a result, Gingko biloba is able to reduce platelet aggregation, and acts on the CPY2C9 and CYP3A4 isoenzymes, inhibiting the microsomial metabolism of warfarin. Therefore, herbal preparations containing Ginkgo biloba should be avoided in patients treated with antiplatelet or anticoagulant drugs [ 125 , 126 ].…”

Section: Herbal Productsmentioning

confidence: 99%

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

et al. 2022

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Drugs and food interact mutually: drugs may affect the nutritional status of the body, acting on senses, appetite, resting energy expenditure, and food intake; conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. Therefore, the knowledge of these possible interactions is fundamental for the implementation of a nutritional treatment in the presence of a pharmacological therapy. This is the case of chronic kidney disease (CKD), for which the medication burden could be a problem, and nutritional therapy plays an important role in the patient’s treatment. The aim of this paper was to review the interactions that take place between drugs and foods that can potentially be used in renal patients, and the changes in nutritional status induced by drugs. A proper definition of the amount of food/nutrient intake, an adequate definition of the timing of meal consumption, and a proper adjustment of the drug dosing schedule may avoid these interactions, safeguarding the quality of life of the patients and guaranteeing the effectiveness of drug therapy. Hence, a close collaboration between the nephrologist, the renal dietitian, and the patient is crucial. Dietitians should consider that food may interact with drugs and that drugs may affect nutritional status, in order to provide the patient with proper dietary suggestions, and to allow the maximum effectiveness and safety of drug therapy, while preserving/correcting the nutritional status.

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Section: Herbal Productsmentioning

confidence: 99%

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

et al. 2022

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“…Furthermore, Ginkgo biloba Extract 50 (GBE50) in combination with aspirin resulted in enhanced antiplatelet effects (demonstrated through both synergistic and additive effects in restraining platelet aggregation) in vitro [ 123 ]. In addition, Ginkgo biloba extract showed antithrombotic effects on endothelial cells demonstrated through increased thrombomodulin expression and tissue-type plasminogen activator secretion in the HUVECs cell model.…”

Section: Phytochemicals With Protective Effects Against Thrombosismentioning

confidence: 99%

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine

et al. 2022

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Thromboembolism is the third leading vascular disease, with a high annual incidence of 1 to 2 cases per 1000 individuals within the general population. The broader term venous thromboembolism generally refers to deep vein thrombosis, pulmonary embolism, and/or a combination of both. Therefore, thromboembolism can affect both – the central and peripheral veins. Arterial thromboembolism causes systemic ischemia by disturbing blood flow and oxygen supply to organs, tissues, and cells causing, therefore, apoptosis and/or necrosis in the affected tissues. Currently applied antithrombotic drugs used, e.g. to protect affected individuals against ischemic stroke, demonstrate significant limitations. For example, platelet inhibitors possess only moderate efficacy. On the other hand, thrombolytics and anticoagulants significantly increase hemorrhage. Contextually, new approaches are extensively under consideration to develop next-generation antithrombotics with improved efficacy and more personalized and targeted application. To this end, phytochemicals show potent antithrombotic efficacy demonstrated in numerous in vitro, ex vivo, and in vivo models as well as in clinical evaluations conducted on healthy individuals and persons at high risk of thrombotic events, such as pregnant women (primary care), cancer, and COVID-19-affected patients (secondary and tertiary care). Here, we hypothesized that specific antithrombotic and antiplatelet effects of plant-derived compounds might be of great clinical utility in primary, secondary, and tertiary care. To increase the efficacy, precise patient stratification based on predictive diagnostics is essential for targeted protection and treatments tailored to the person in the framework of 3P medicine. Contextually, this paper aims at critical review toward the involvement of specific classes of phytochemicals in antiplatelet and anticoagulation adapted to clinical needs. The paper exemplifies selected plant-derived drugs, plant extracts, and whole plant foods/herbs demonstrating their specific antithrombotic, antiplatelet, and fibrinolytic activities relevant for primary, secondary, and tertiary care. One of the examples considered is antithrombotic and antiplatelet protection specifically relevant for COVID-19-affected patient groups.

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“…Reports have shown that ginkgolides and sesquiterpene protect mitochondria from age-related damage and improve mitochondrial function and energy metabolism [ 26 , 27 , 28 ]. There are two possible molecular mechanisms for mitochondrial protection: antagonism of platelet-activating factor receptor (PAF, 1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine) [ 29 , 30 , 31 ] and chloride channels [ 32 , 33 , 34 ]. More than 30 genuine flavonoids are found in ginkgo biloba.…”

Section: Introductionmentioning

confidence: 99%

Blending Technology Based on HPLC Fingerprint and Nonlinear Programming to Control the Quality of Ginkgo Leaves

Liu

Jin

et al. 2022

Molecules

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The breadth and depth of traditional Chinese medicine (TCM) applications have been expanding in recent years, yet the problem of quality control has arisen in the application process. It is essential to design an algorithm to provide blending ratios that ensure a high overall product similarity to the target with controlled deviations in individual ingredient content. We developed a new blending algorithm and scheme by comparing different samples of ginkgo leaves. High-consistency samples were used to establish the blending target, and qualified samples were used for blending. Principal component analysis (PCA) was used as the sample screening method. A nonlinear programming algorithm was applied to calculate the blending ratio under different blending constraints. In one set of calculation experiments, the result was blended by the same samples under different conditions. Its relative deviation coefficients (RDCs) were controlled within ±10%. In another set of calculations, the RDCs of more component blending by different samples were controlled within ±20%. Finally, the near-critical calculation ratio was used for the actual experiments. The experimental results met the initial setting requirements. The results show that our algorithm can flexibly control the content of TCMs. The quality control of the production process of TCMs was achieved by improving the content stability of raw materials using blending. The algorithm provides a groundbreaking idea for quality control of TCMs.

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The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation

Cited by 27 publications

References 76 publications

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

Antithrombotic and antiplatelet effects of plant-derived compounds: a great utility potential for primary, secondary, and tertiary care in the framework of 3P medicine

Blending Technology Based on HPLC Fingerprint and Nonlinear Programming to Control the Quality of Ginkgo Leaves

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