The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy

Pottoo, Faheem Hyder; Tabassum, Nahida; Javed, Nazir; Nigar, Shah; Rasheed, Rouqia; Khan, Ayash; Barkat, Md. Abul; Alam, Md Sabir; Maqbool, Amir; Ansari, Mohammad Azam; Barreto, George E.; Ashraf, Ghulam Md

doi:10.1007/s12035-018-1121-x

Cited by 48 publications

(18 citation statements)

References 82 publications

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“…NPY is also synthesized and released from peripheral sympathetic nerve system [12,13]. NPY is involved in modulating stress related disorders, such as anxiety, depression, and post-traumatic stress disorder (PTSD) [14,15], and may even the epilepsy [16]. NPY is involved in the termination of the stress and anxiety response by inhibiting the biological actions of CRF [17].…”

Section: Introductionmentioning

confidence: 99%

Intranasal Administration of Neuropeptide Y Significantly Antagonized Chronic Stress Responses via Central Gabaa Receptors in Male Rats

Yu¹,

Yu²,

Babygirija

et al. 2021

Preprint

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Stress is widely believed to play a major role in the pathogenesis of many diseases. Central neuropeptide Y (NPY) counteracts the biological actions of corticotropin-releasing factor (CRF), and in turn attenuates stress responses. Administration (intracerebroventricular, ICV) of NPY, significantly antagonized the inhibitory effects of chronic complicated stress (CCS) on gastrointestinal (GI) dysmotility in rats. However, ICV administration is an invasive technique. The effect of intranasal administration of NPY on the hypothalamus-pituitary-adrenal (HPA) axis and GI motility in CCS conditions have not been studied, and the inhibitory mechanism of NPY on CRF through the gamma-aminobutyric acid (GABA)A receptor needs to be further investigated. A CCS rat model was set up, NPY was intranasal administered every day prior to the stress loading. Further, a GABAA receptor antagonist was ICV injected daily. Central CRF and NPY expression were evaluated, serum corticosterone and NPY levels were analyzed, and colonic motor functions was assessed. CCS rats showed significantly increased CRF expression and corticosterone levels, which resulted in enhanced colonic motor functions. Intranasal NPY significantly increased central NPY mRNA expression and reduced central CRF mRNA expression as well as the plasma corticosterone level, helping to restore colonic motor functions. However, ICV administration of the GABAA receptor antagonist significantly abolished these effects. Intranasal administration of NPY upregulates the hypothalamic NPY system. NPY may, through the GABAA receptor, significantly antagonize the overexpressed central CRF and attenuate the HPA axis activities in CCS conditions, exerting influences and helping to restore colonic motor function.

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Section: Introductionmentioning

confidence: 99%

Intranasal Administration of Neuropeptide Y Significantly Antagonized Chronic Stress Responses via Central Gabaa Receptors in Male Rats

Yu¹,

Yu²,

Babygirija

et al. 2021

Preprint

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“…Epilepsy is one of the most undefined diseases of the human CNS that can affect all age groups. Despite ongoing research and studies to explain the exact underlying mechanism of epilepsy and the time and effort required to discover new antiepileptic drugs, the results of epilepsy remission are still insufficient [1][2] . Current therapeutic regimens like phenytoin, valproate and carbamazepine have been valued in treating 50% of partial seizures and 60-70% of generalized seizures 3 .…”

Section: Introductionmentioning

confidence: 99%

Studies on New Schiff bases of Benzoxazole: Synthesis, Anticonvulsant and Neurotoxicity Evaluation

Sarafroz¹,

Alameer²,

Alturaiki³

et al. 2020

Orient. J. Chem

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Twelve Schiff bases of benzoxazole were prepared by usage of methyl-3-amino-4hydroxybenzoate. The chemistry of the prepared molecules was established based on the spectral data and tested for anticonvulsant activity using maximal electroshock (MES) induced seizure and subcutaneous pentylenetetrazole (scPTZ). In addition, a rotarod method to detect minimal neurological impairment in mice. In anti-MES test molecules 3d, 3e, 3i, 3j and 3k presented effective action corresponding to hydrophobicity. Other compounds of the series like 3b, 3c, 3g and 3l were remarkably less lipophilic and have some potencies. Compounds 3d and 3j effectively passed the rotarod trial without any mark of CNS deficit. In conclusion, the synthesized compounds with distal aryl groups showed higher hydrophobicity and resulted in better pharmacological action, which can be the future of new promising anticonvulsant drugs.

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“…Recently, gold nanoparticles are emerging as unique, efficient, simple and reliable solutions for scientific and technical challenges of existing processes, machines or systems in various disciplines of engineering sciences . Discovery of new drugs or pharmaceutical combinations for the treatment of many life threating complex clinical conditions such as opportunistic infections, delayed wound healing, MDR (Multidrug resistance) bacterial and cancerous diseases, as well as epilepsy; not only required suitability and rationality in approaches and their selection but also proven to be time consuming exercise at the cost of exploiting limited and valuable resources in bulk . Most of the conventional nanoparticles and catalytic reactions facing limited success in term of efficiency of reaction yield as well as requires strict controlling of desired conditions .…”

Section: Introductionmentioning

confidence: 99%

QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye

Alam

Javed

Pottoo

et al. 2019

Applied Organom Chemis

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Microwave irradiation (MI) process characteristically enables extremely rapid “in‐core” heating of dipoles and ions, in comparison to conventional thermal (conductance) process of heat transfer. During the process of nanoparticles synthesis, MI both modulates functionality behaviors as well as dynamic of reaction in favorable direction. So, MI providing a facile, favorable and alternative approach during nanoparticles synthesis nanoparticles with enhanced catalytic performances. Although, conventionally used reducing and capping reagents of synthetic origin, are usually environmentally hazardous and toxic for living organism. But, in absence of suitable capping agent; stability, shelf life and catalytic activity of metallic nanoparticles adversely affected. However, polymeric templates which emerged as suitable choice of agent for both reducing and capping purposes; bearing additional advantages in terms of catalyst free one step green synthesis process with high degree of biosafety and efficiency. Another aspect of current works was to understand role of process variables in growth mechanism and catalytic performances of microwave processed metallic nanoparticles, as well as comparison of these parameters with conventional heating method. However, due to poor prediction ability with previously published architect OFAT (One factor at a time) design with these nanoparticles as well as random selection of process variables with their different levels, such comparison couldn't be possible. Hence, using gum Ghatti (Anogeissus latifolia) as a model bio‐template and under simulated reaction conditions; architect of QbD design systems were integrated in microwave processed nanoparticles to establish mechanistic role these variables. Furthermore, in comparison to conventional heating; we reported well validated mathematical modeling of process variables on characteristic of nanoparticles as well as synthesized gold nanoparticles of desired and identical dimensions, in both thermal and microwave‐based processes. Interestingly, despite of identical dimension, MI processed gold nanoparticles bearing higher efficiency (kinetic rate) against remediation of hazardous nitro dye (4‐nitrophenol), into safer amino (4‐aminophenol) analogues.

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The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy

Cited by 48 publications

References 82 publications

Intranasal Administration of Neuropeptide Y Significantly Antagonized Chronic Stress Responses via Central Gabaa Receptors in Male Rats

Intranasal Administration of Neuropeptide Y Significantly Antagonized Chronic Stress Responses via Central Gabaa Receptors in Male Rats

Studies on New Schiff bases of Benzoxazole: Synthesis, Anticonvulsant and Neurotoxicity Evaluation

QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye

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