The synergistic effect of vitamin D supplement and mindfulness training on pain severity, pain-related disability and neuropathy-specific quality of life dimensions in painful diabetic neuropathy: a randomized clinical trial with placebo-controlled

Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review

“…The basic details of the studies included in the systematic review [26][27][28][29][30][31] are presented in Table 2. The included studies that evaluated the influence of vitamin D supplementation on the mental health of diabetic patients were conducted mainly in Iran [29][30][31], and also in the United States of America [28], Canada [27], and the Netherlands [26]. The study sample comprised patients recruited from the specific clinics of the hospitals [27,29,31] or from general practitioners [26].…”

“…The included studies that evaluated the influence of vitamin D supplementation on the mental health of diabetic patients were conducted mainly in Iran [29][30][31], and also in the United States of America [28], Canada [27], and the Netherlands [26]. The study sample comprised patients recruited from the specific clinics of the hospitals [27,29,31] or from general practitioners [26]. Some groups were recruited to be characterized by specific diabetes complications, such as chronic kidney disease [27] or painful diabetic neuropathy [31].…”

“…The study sample comprised patients recruited from the specific clinics of the hospitals [27,29,31] or from general practitioners [26]. Some groups were recruited to be characterized by specific diabetes complications, such as chronic kidney disease [27] or painful diabetic neuropathy [31]. Some studies included patients suffering from mental health problems, such as anxiety [29] or depressive symptomatology [28,30], while some included patients were diagnosed with vitamin D deficiency only [29,31].…”

“…Some groups were recruited to be characterized by specific diabetes complications, such as chronic kidney disease [27] or painful diabetic neuropathy [31]. Some studies included patients suffering from mental health problems, such as anxiety [29] or depressive symptomatology [28,30], while some included patients were diagnosed with vitamin D deficiency only [29,31]. The basic characteristics of the participants of the studies included in the systematic review are presented in Table 3.…”

“…The studies included in this systematic review were conducted mainly in small samples of participants (less than 100 individuals) [28][29][30] or larger samples comprising more than 100 [26,27] or 200 individuals [31], while some studies were performed in smaller but homogenous samples comprising exclusively female individuals [28,29]. The inclusion criteria were based mainly on the diagnosis of type 2 diabetes mellitus [26,[28][29][30][31], type 1 or type 2 diabetes mellitus [27], a specified clinical condition, and applied treatment, as well as the presence of specific diabetes complications, such as chronic kidney disease [27] or diabetic neuropathy [31]. The basic description of the exposure and outcomes within the studies included to the systematic review is presented in Table 4.…”